益气养阴汤联合卡介苗免疫治疗对卵巢癌患者免疫功能及生活质量的影响

发布时间：2018-04-27 11:46

本文选题：益气养阴汤 + 卡介苗　；参考：《中华中医药学刊》2017年12期

【摘要】：目的:分析益气养阴汤联合卡介苗免疫治疗对卵巢癌患者免疫功能及生活质量的影响。方法:选取2015年6月—2016年12月医院肿瘤科接收的120例癌症患者,经病理证实为卵巢癌,按随机数字法分为对照组和观察组。对照组采用采用口服卡介苗免疫治疗;观察组在对照组治疗的基础上联合益气养阴汤治疗。详细记录患者治疗前、后血液中CD_4~+、CD_8~+、NK及CD_4~+/CD_8~+比值。并记录患者的卡氏评分、体质量及临床治疗效果。结果:治疗后,患者的卡氏评分及体质量明显提高,但观察组患者的卡氏评分(73.92±4.67)分、体质量(57.19±2.49)kg明显高于对照组卡氏评分(66.54±5.12)、体质量(55.71±2.34)(P0.05)。治疗后,两组患者的免疫指标均有明显改善;但观察组的CD_4~+(37.16±2.26)、CD_8~+(20.28±2.81)、NK(42.73±3.46)及CD_4~+/CD_8~+(1.78±0.15)明显高于对照组CD_4~+(35.27±2.18)、CD_8~+(21.18±2.73)、NK(40.18±3.25)及CD_4~+/CD_8~+(1.64±0.13)(P0.05)。观察组治疗的有效率91.67%(55/60)明显高于对照组的有效率81.67%(49/60)(P0.05)。观察组的不良反应发生率13.33%(8/60)明显低于对照组不良反应发生率25.00%(15/60)(P0.05)。结论:益气养阴汤联合卡介苗免疫治疗卵巢癌,可明显改善患者免疫状况,提高治疗效果,增强患者的生活质量,值得临床推广借鉴。
[Abstract]:Objective: to analyze the effect of Yiqi Yangyin decoction combined with BCG immunotherapy on immune function and quality of life of patients with ovarian cancer. Methods: 120 cancer patients from June 2015 to December 2016 were randomly divided into two groups: control group and observation group. The control group was treated with oral BCG immunotherapy, and the observation group was treated with Yiqi Yangyin decoction on the basis of the control group. Before and after treatment, the CD4 / CD8 / NK and CD4 / / CD8 / T ratio in blood were recorded in detail. The patients' Cardahl score, body mass and clinical effect were recorded. Results: after treatment, the Karnoff score and body mass of the patients increased significantly, but in the observation group, the score was 73.92 卤4.67, and the body weight was 57.19 卤2.49)kg significantly higher than that in the control group (66.54 卤5.12), and the body weight was 55.71 卤2.34 (P 0.05). After treatment, the immunological indexes of the two groups were significantly improved, but the CD4 ~ + (37.16 卤2.26) of the observation group was significantly higher than that of the control group (CD4 ~ 35.27 卤2.18 卤2.73 卤3.25) and CD4- / -CDT _ (8) / P _ (0.05), and CD4- / -CDT _ (8) 卤0.13P _ (0.05) was significantly higher than that of the control group (P < 0.05), but in the observation group, the CD8- (20.28 卤2.81) and the CD4- /-_ (0.13) were significantly higher than those in the control group (P < 0.05), and in the observation group, the levels of CD4- /-/ -CDT were 1.64 卤0.13P _ (0.05) and 1.64 卤0.13 respectively. The effective rate of treatment in the observation group (91.67%) was significantly higher than that in the control group (81.67%). The incidence of adverse reactions in the observation group (13.33 / 60) was significantly lower than that in the control group (25.00 / 60). Conclusion: the combination of Yiqi Yangyin decoction and BCG vaccine in the treatment of ovarian cancer can obviously improve the immune status of the patients, improve the therapeutic effect and enhance the quality of life of the patients, which is worthy of clinical popularization and reference.
【作者单位】：青岛市妇女儿童医院妇科;
【基金】：山东省自然科学基金项目(ZR2012CM028)
【分类号】：R737.31

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