~1H磁共振波谱在非小细胞肺癌脑转移放疗疗效评价中的预测价值

发布时间：2018-04-28 09:49

  本文选题：H磁共振波谱 + 非小细胞肺癌　； 参考：《中国医科大学学报》2017年12期

【摘要】：目的探讨~1H磁共振波谱(~1H-MRS)在非小细胞肺癌(NSCLC)脑转移放疗疗效评价中的预测价值。方法接受立体定向放疗(SRT)联合全脑照射(WBRT)的56例NSCLC脑转移患者在治疗前应用~1H-MRS进行检查,测量Cho/Cr的比值,比较治疗前Cho/Cr比值高组与Cho/Cr比值低组间疗效的差异,分析~1H-MRS在NSCLC脑转移放疗疗效评价中的预测价值。结果治疗前Cho/Cr比值中位值为1.989。治疗前Cho/Cr比值高组(1.989)1、3、5年生存率分别为29.3%(95%CI:11.3%~47.3%)、0%、0%,平均生存时间为9.77个月(95%CI:7.50~12.04个月)。Cho/Cr比值低组(1.989)1、3、5年生存率分别为70.5%(95%CI:53.3%~87.7%)、22.3%(95%CI:6.6%~38.0%)、1.8%(95%CI:0~8.1%),平均生存时间为24.67个月(95%CI:17.69~31.66个月)。治疗前Cho/Cr比值高组与Cho/Cr比值低组比较平均生存时间有统计学差异(P0.05)。结论 ~1H-MRS对NSCLC脑转移放疗的疗效评价具有预测价值,治疗前Cho/Cr比值高组预后差。
[Abstract]:Objective to evaluate the predictive value of 1H magnetic resonance spectroscopy (1H-MRS) in brain metastasis radiotherapy of NSCLC patients with non small cell lung cancer (NSCLC). Methods 56 patients with NSCLC brain metastasis received stereotactic radiotherapy combined with whole brain irradiation were examined with 1H-MRS before treatment, the ratio of Cho/Cr was measured, and the difference of curative effect between the high Cho/Cr ratio group and the low Cho/Cr ratio group before treatment was compared. To analyze the predictive value of 1 H Mrs in NSCLC brain metastasis radiotherapy. Results the median value of Cho/Cr ratio before treatment was 1.989. 娌荤枟鍓岰ho/Cr姣斿，

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