neoplasm tumor microenvironment drug delivery system

  本文关键词：肿瘤靶向递药新策略的研究进展，由笔耕文化传播整理发布。

肿瘤靶向递药新策略的研究进展

The development of novel tumor targeting delivery strategy

[1] [2]

GAO Hui-le,JIANG Xin-guo（1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610

[1]四川大学华西药学院、靶向药物与释药系统教育部重点实验室,四川成都610041; [2]复旦大学药学院、教育部智能化递药重点实验室,上海201203

文章摘要：肿瘤已成为危害人类健康和生命的第二大疾病。尽管已有多种抗肿瘤药物上市,但是由于肿瘤靶向性不佳,肿瘤内蓄积能力较差,使得抗肿瘤效果不尽如人意。如何高效地将抗肿瘤药物递送入肿瘤,提高药物在肿瘤部位的浓度,降低其在正常组织中的浓度,成为制药领域研究的热点。为达到此目的,研究者设计了多种纳米靶向递药系统,并取得了一定的效果。本文将对目前已有的肿瘤靶向递药策略进行综述,对其中存在的问题进行讨论。

Abstr：Tumor is one of the most serious threats for human being. Although many anti-tumor drugs are approved for clinical use, the treatment outcome is still modest because of the poor tumor targeting efficiency and low accumulation in tumor. Therefore, it is important to deliver anti-tumor drug into tumor efficiently, elevate drug concentration in tumor tissues and reduce the drug distribution in normal tissues. And it has been one of the most attractive directions of pharmaceutical academy and industry. Many kinds of strategies, especially various nanoparticulated drug delivery systems, have been developed to address the critical points of complex tumor microenvironment, which are partially or mostly satisfied for tumor treatment. In this paper, we carefully reviewed the novel targeting delivery strategies developed in recent years. The most powerful method is passive targeting delivery based on the enhanced permeability and retention（EPR） effect, and most commercial nanomedicines are based on the EPR effect. However, the high permeability and retention require different particle sizes, thus several kinds of size-changeable nanoparticles are developed, such as size reducible particles and assemble particles, to satisfy the controversial requirement for particle size and enhance both tumor retention and penetration. Surface charge reversible nanoparticles also shows a high efficiency because the anionic charge in blood circulation and normal organs decrease the unintended internalization. The charge can change into positive in tumor microenvironment, facilitating drug uptake by tumor cells. Additionally, tumor microenvironment responsive drug release is important to decrease drug side effect, and many strategies are developed, su

文章关键词：

Keyword：:neoplasm tumor microenvironment drug delivery system

课题项目：国家自然科学基金资助项目（31571016;81402866）

作者信息：会员可见

  本文关键词：肿瘤靶向递药新策略的研究进展，，由笔耕文化传播整理发布。