老年晚期非小细胞肺癌氩氦刀冷冻治疗前后证型变化规律探讨

发布时间：2018-05-01 19:27

本文选题：老年晚期肺癌 + 氩氦刀　；参考：《中华中医药杂志》2017年04期

【摘要】：目的:研究老年晚期非小细胞肺癌患者氩氦刀冷冻治疗前后的证候类型分布及变化规律,探讨主要证候要素及其影响因素。方法:共收集104例患者,分别于术前1天、术后1周、术后1个月、术后3个月进行辨证,总结证候类型变化规律。结果:(1)104例患者在4个时点共出现27个中医证型,主要以气虚痰湿、气虚痰湿+其他要素、气虚+其他要素3种形式为主。(2)获取病性类证候要素共8个,出现频次排前4位的有气虚(84例)、痰湿(61例)、阴虚(63例)、血瘀(23例)。各时点气虚证素证素频次在疾病发展过程中始终保持较高水平。(3)在证型虚实方面,各时点均以虚实夹杂证最多,虚实夹杂证术后3月例数(74例)比术前(59例)增多,差异具有统计学意义(P0.05)。(4)气虚为最主要的证候要素,其影响因素为年龄和PS评分,随着年龄增长和PS评分升高,气虚发生风险越高。结论:气虚合并其他要素是老年晚期非小细胞肺癌患者贯穿氩氦刀冷冻治疗前后最主要的证型;年龄75岁和PS评分升高,气虚发生风险更高。
[Abstract]:Objective: to study the distribution and changes of syndromes in elderly patients with advanced non-small cell lung cancer (NSCLC) before and after cryotherapy with argon and helium (Argon-helium knife), and to explore the main syndromes and their influencing factors. Methods: one day before operation, one week after operation, one month after operation and three months after operation, 104 patients were divided into two groups. Results there were 27 TCM syndromes in 104 patients at 4 time points. The main factors were qi deficiency and phlegm dampness, qi deficiency phlegm dampness, Qi deficiency and other factors. There were 84 cases with Qi deficiency, 61 cases with phlegm dampness, 63 cases with Yin deficiency and 23 cases with blood stasis. Qi-deficiency syndrome factor frequency of each time point in the disease development process has always maintained a high level. (3) in the syndrome type of deficiency and reality, the most of all time points are deficiency and solid inclusion syndrome, the number of patients with deficiency and deficiency syndrome 3 months after operation (74 cases) is more than that before operation (59 cases). The difference was statistically significant (P0.05P0.05U. 4) deficiency of Qi was the most important factor of syndromes, and its influencing factors were age and PS score. With the increase of age and PS score, the risk of Qi deficiency was higher. Conclusion: Qi deficiency combined with other factors is the most important type of syndrome in elderly patients with advanced non-small cell lung cancer before and after cryotherapy with argon-helium knife, the age of 75 years old and PS score increase, and the risk of Qi deficiency is higher.
【作者单位】：首都医科大学附属北京世纪坛医院中医科;中国中医科学院西苑医院创伤科;北京中医药大学东方医院肿瘤科;
【基金】：北京市中医药科技发展资金项目(No.QN2014-06) 北京市中西医结合肿瘤研究所建设项目北京中医药大学东方医院人才培养计划“东方名医” 首都医科大学附属北京世纪坛医院院青年基金项目(No.2014-Q16) 北京市中西医结合肿瘤诊疗中心~~
【分类号】：R734.2

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