肝内胆管细胞癌预后相关因素的分析

发布时间：2018-05-02 00:58

本文选题：肝内胆管癌 + 预后因素　；参考：《上海交通大学》2015年硕士论文

【摘要】：目的:本研究通过对肝内胆管癌(Intrahepatic cholangiocarcinoma,ICC)患者的回顾性研究,探讨ICC患者的预后相关影响因素,同时分析CA242与ICC患者预后不良的相关性。方法:收集2001年2月至2010年2月间在上海交通大学医学院附属新华医院行手术治疗且术后病理已证明的41例ICC患者的临床病例资料,通过回顾性研究分析全组患者的生存情况及其预后相关影响因素。结果:本队列中41例ICC患者的总体1年、3年和5年总体生存率分别为63.4%、48.8%和29.3%。多发性肿瘤(RR=3.054,P=0.006)、肿瘤分化程度(RR=3.431,P=0.001)、淋巴结转移(RR=2.633,P=0.02)与ICC长期不良预后有明显相关性。CA242独立检测与ICC的预后不良无明显的相关性,但其与CA199联合检测(RR=1.911,P=0.045)与ICC的不良预后有一定的相关性。结论:多发性肿瘤、肿瘤分化程度和淋巴结转移是ICC长期生存预后不良的独立影响因素;肿瘤标记物联合检测可提高预测ICC不良预后的相关性。
[Abstract]:Objective: to investigate the prognostic factors of patients with intrahepatic cholangiocarcinoma (ICC) by retrospective study, and to analyze the correlation between CA242 and poor prognosis in patients with ICC. Methods: from February 2001 to February 2010, the clinical data of 41 patients with ICC who were treated surgically and pathologically proved at Xinhua Hospital affiliated to Shanghai Jiaotong University Medical College were collected. The survival and prognostic factors of the patients were analyzed retrospectively. Results: the overall 1-year, 3-year and 5-year survival rates of 41 patients with ICC in this cohort were 48.8% and 29.3%, respectively. There was a significant correlation between RRN 3.054 and P0. 006, the degree of tumor differentiation and lymph node metastasis were significantly correlated with the long-term poor prognosis of ICC. There was no significant correlation between the independent detection of CA242 and the poor prognosis of ICC, but there was a certain correlation between RR1. 911P0. 045) and the poor prognosis of ICC. Conclusion: multiple tumors, tumor differentiation and lymph node metastasis are independent factors influencing the long-term survival and prognosis of ICC, and the combined detection of tumor markers can improve the correlation of predicting the poor prognosis of ICC.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.8

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