活络效灵丹辨证辅助治疗对中重度癌性疼痛的镇痛效应研究

发布时间：2018-05-02 22:56

本文选题：癌性疼痛 + 活络效灵丹　；参考：《重庆医学》2017年10期

【摘要】：目的探讨活络效灵丹辨证辅助治疗对中重度癌性疼痛的镇痛效应及机制研究。方法将206例患者分为对照组104例和观察组102例。对照组,中度疼痛患者采用布洛芬片+盐酸羟考酮缓释片;重度疼痛采用布洛芬片+硫酸吗啡缓释片。观察组在对照组的基础上采用活络效灵丹辨证。疗程均为10d。采用疼痛视觉模拟评分(VAS)记录患者疼痛情况;进行治疗前后简明疼痛评估量表和生活质量评分;检测治疗前后P物质(SP)、β-内啡肽(β-EP)和前列腺素E2(PGE2)水平。结果观察组疼痛缓解率为94.12%,高于对照组的81.73%(χ~2=7.409,P0.01);观察组在第5~10天VAS评分均低于对照组(P0.01);观察组疼痛最剧程度、疼痛最轻程度、平均疼痛程度和目前疼痛程度评分均低于对照组(P0.01);观察组情绪等疼痛影响评分均低于对照组(P0.01);观察组患者的生活质量情况优于对照组(P0.05);观察组SP和PGE2低于对照组,β-EP水平高于对照组(P0.01)。结论活络效灵丹辨证辅助治疗中重度癌性疼痛,能减轻患者疼痛,改善疼痛导致的影响,提高患者的生活质量,其作用机制可能与降低SP和PGE2,升高β-EP有关。
[Abstract]:Objective to investigate the analgesic effect and mechanism of the auxiliary treatment of activating collaterals and panacea to treat moderate to severe cancer pain. Methods 206 patients were divided into control group (104 cases) and observation group (102 cases). The control group was treated with Ibuprofen Tablets + Oxycodone Hydrochloride Prolonged-release Tablets for moderate pain and severe pain by Ibuprofen Tablets + Morphine Sulfate Sustained-release Tabelets. On the basis of the control group, the pain situation of the patients was recorded by 10d. with the visual analogue score (VAS); the simple pain assessment scale and the quality of life score before and after treatment; the level of P substance (SP), beta endorphin (beta -EP) and prostaglandin E2 (PGE2) before and after treatment. Results the pain relief rate of the observation group. 94.12%, higher than the control group of 81.73% (x ~2=7.409, P0.01), the observation group on day 5~10 VAS scores were lower than the control group (P0.01); the pain most of the observation group, the least pain degree, the average pain degree and the current pain degree scores were lower than the control group (P0.01); the observation group emotional pain impact scores were lower than the control group (P0.01); observation group (P0.01); observation group (P0.01); observation group The quality of life of the patients was better than that of the control group (P0.05), and the SP and PGE2 in the observation group were lower than the control group, and the level of beta -EP was higher than that of the control group (P0.01). Conclusion the syndrome differentiation assisted treatment for moderate and severe cancer pain can relieve the pain, improve the effect of pain and improve the quality of life of the patients. The mechanism of the action may be reduced by SP and PGE2, The increase of beta -EP is related.

【作者单位】：河北省邢台市人民医院中医内科;
【分类号】：R730.5

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