Notch-Hes信号通路异常与急性白血病

发布时间：2018-05-03 14:39

  本文选题：Notch + Hes　； 参考：《中国实验血液学杂志》2017年01期

【摘要】：Notch信号的异常活化与急性白血病的关系密切。Notch信号通路的核心组件包括Notch受体、Notch配体、CSLDNA结合蛋白、下游靶基因等效应分子等4部分。任何影响配体、受体、信号转导分子及效应分子的因素都会对Notch信号通路的传递产生影响。基于异常Notch信号在急性白血病中的重要作用,目前已经开发出了多种针对Notch上游信号的靶向药物,但是由于Notch信号的复杂性、多效性,现有针对Notch上游信号的靶向药物毒副作用较多。Hes基因家族是Notch信号中一个非常重要的靶基因,并且与白血病发生之间的关系密切。本文简述了该研究领域的新进展,期望Hes蛋白或基因的深入研究能为研发新一代靶向药物提供参考。
[Abstract]:Abnormal activation of Notch signal is closely related to acute leukemia. The core components of Notch signaling pathway include Notch receptor Notch ligand CSL DNA-binding protein, downstream target gene and other effector molecules. Any factors affecting ligand, receptor, signal transduction molecule and effector molecule will affect the transmission of Notch signal pathway. Based on the important role of abnormal Notch signal in acute leukemia, a variety of targeted drugs for upstream Notch signal have been developed, but because of the complexity and efficiency of Notch signal, There are many drug toxicity and side effects targeting upstream Notch signal. Hes gene family is a very important target gene in Notch signal and has a close relationship with leukaemia. In this paper, the recent progress in this field is briefly reviewed. It is hoped that the further study of Hes protein or gene can provide a reference for the development of a new generation of targeted drugs.
【作者单位】： 解放军医学院解放军总医院血液科;
【基金】：国家自然科学基金面上项目(81270642)
【分类号】：R733.71
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本文编号：1838911