直肠癌低位前切除术后吻合口瘘发生相关因素分析

发布时间：2018-05-03 20:31

本文选题：直肠癌 + 低位前切除　；参考：《首都医科大学学报》2017年05期

【摘要】：目的探究直肠癌低位前切除术后发生吻合口瘘的危险因素,为临床上吻合口瘘的防治提供依据,从而降低瘘的发生率。方法回顾性分析2013年1月1日至2017年3月31日首都医科大学附属北京友谊医院261例行直肠癌低位前切除术(low anterior resection,LAR)病人的临床资料。分别行单因素和Logistic多因素回归分析吻合口瘘的相关危险因素。结果吻合口瘘发生率为6.89%(18/261)。多因素分析显示,新辅助放射治疗联合化学药物治疗(以下简称放化疗)(OR=3.498,P=0.024)、联合其他器官手术(OR=10.834,P=0.003)与术后吻合口瘘相关。结论新辅助放化疗、联合其他器官手术为直肠癌低位前切除术后吻合口瘘的独立危险因素。针对相关危险因素,可以采取积极有效的防治措施,从而降低吻合口瘘的发生。
[Abstract]:Objective to investigate the risk factors of anastomotic leakage after low anterior resection of rectal cancer, and to provide evidence for prevention and treatment of anastomotic fistula in clinic, so as to reduce the incidence of anastomotic fistula. Methods from January 1, 2013 to March 31, 2017, the clinical data of 261 patients with low anterior resectionlare treated in Beijing Friendship Hospital affiliated to Capital Medical University were retrospectively analyzed. The risk factors of anastomotic fistula were analyzed by univariate and Logistic multivariate regression analysis. Results the incidence of anastomotic leakage was 6.89%. Multivariate analysis showed that neoadjuvant radiotherapy combined with chemotherapeutic therapy (OR3. 498P0. 024, OR10. 834, P0. 003) was associated with postoperative anastomotic fistula. Conclusion Neoadjuvant chemotherapy combined with other organ surgery is an independent risk factor for anastomotic fistula after low anterior resection of rectal cancer. According to the related risk factors, active and effective prevention and treatment measures can be taken to reduce the occurrence of anastomotic leakage.
【作者单位】：首都医科大学附属北京友谊医院普外科国家消化系统疾病临床医学研究中心;
【基金】：首都卫生发展科研专项项目(2014-2-2022)~~
【分类号】：R735.37

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