广州地区男男性接触者肛门人类乳头瘤病毒感染现况及危险因素分析

发布时间：2018-05-04 06:47

本文选题：人类乳头瘤病毒 + 男男性接触者　；参考：《广东医学》2017年21期

【摘要】：目的分析广州地区男男性接触者(MSM)肛门人类乳头瘤病毒(HPV)感染现况及危险因素。方法在广州地区招募MSM者,进行人口学资料、性行为等调查,采集血液及肛门拭子标本行HIV及HPV分型检测。采用Multivariate logistic回归模型分析HPV感染危险因素。结果共调查MSM 168例,其中HIV阳性72例,感染率42.8%。共有127例患者检测出至少一种HPV感染,任一型别HPV感染率75.6%,其中混合型39.3%,单纯高危型13.7%,单纯低危型22.6%。HIV阳性者HPV感染率显著高于HIV阴性者(P0.05)。对于总体MSM人群,HIV阳性是其感染任一型别HPV(RR=8.548,P0.001)、高危型HPV(RR=9.264,P0.001)、低危型HPV(RR=3.113,P=0.005)的主要危险因素。对于HIV阳性MSM人群,CD4~+淋巴细胞计数500 cells/μL及HIV_1-RNA载量1×10~5copies/mL是其感染任一型别、高危型及低危型HPV的独立危险因素(均P0.05)。对于HIV阴性MSM人群,具有其他性传播疾病(STD)者感染任一型别、高危型及低危型HPV的相对风险是无STD者的2.9、1.0、1.6倍(均P0.05)。结论广州地区MSM肛门HPV感染率高,以混合型HPV为主。HIV阳性是MSM肛门HPV感染的主要独立危险因素。
[Abstract]:Objective to analyze the prevalence and risk factors of anal human papillomavirus (HPV) infection in MSM in Guangzhou. Methods MSM was recruited in Guangzhou area. The demographic data and sexual behavior were investigated. Blood and anal swabs were collected for HIV and HPV typing. Multivariate logistic regression model was used to analyze the risk factors of HPV infection. Results A total of 168 cases of MSM were investigated, of which 72 cases were positive for HIV, and the infection rate was 42.8%. A total of 127 patients detected at least one type of HPV infection. The infection rate of any type of HPV was 75.60.Among them, the mixed type was 39.3%, the high risk type was 13.7.The infection rate of HPV in the patients with simple low-risk 22.6%.HIV positive was significantly higher than that in the HIV negative patients (P 0.05). MSM positive was the main risk factor for any type of HPV-RRN (8.548%), high risk type (RPV-9.264) (P0.001), and low risk type (HPV-RRN 3.113% P0.005). For the HIV positive MSM population, the CD4 ~ Lymphocyte count of 500 cells/ 渭 L and the HIV_1-RNA load of 1 脳 10~5copies/mL were the independent risk factors for any type of HPV infection, high risk type and low risk type (all P 0.05). For HIV negative MSM patients, the relative risk of HPV in high risk type and low risk type was 1. 6 times higher than that of non STD group (all P 0. 05), and the relative risk of HPV in high risk type and low risk group was 1. 6 times as high as that in non STD group (all P 0. 05%). Conclusion the infection rate of MSM anus HPV is high in Guangzhou area. Mixed HPV is the main independent risk factor for MSM anal HPV infection.
【作者单位】：广州市第八人民医院皮肤科;
【基金】：广州市医药卫生科技项目(编号:20151A010053)
【分类号】：R512.91;R735.3

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