肿瘤细胞减灭加腹腔热灌注化疗术后静脉血栓栓塞症的预防

发布时间：2018-05-05 00:32

本文选题：静脉血栓栓塞症 + 物理预防　；参考：《中国肿瘤临床》2017年08期

【摘要】：目的:评估行肿瘤细胞减灭术(cytoreductive surgery,CRS)加腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)治疗的腹膜癌患者静脉血栓栓塞症(venous thromboembolism,VTE)发生风险,研究术后早期主/被动活动联合间歇充气加压按摩对VTE的预防效果。方法:对2015年5月至2016年8月武汉大学中南医院肿瘤科收治的120例胃肠道及妇科肿瘤等来源的腹膜癌患者行CRS+HIPEC治疗,使用Caprini血栓风险评估模型评价VTE风险,所有患者采取早期肢体主/被动活动及间歇充气加压按摩治疗,记录分析VTE相关事件。结果:患者中位Carprini评分为12(10~16)分,均为VTE极高危组,在3个月的随访中仅1例患者发生深静脉血栓,经药物治疗后痊愈。结论:腹膜癌患者VTE风险极高,术后早期足背曲/跖曲及扩胸等主/被动运动联合间歇充气加压按摩,可有效预防VTE。
[Abstract]:Objective: to evaluate the risk of venous thromboembolism (VTE) in patients with peritoneal cancer treated by cytoreductive cytotoxicity (CRS) plus hyperthermic intraperitoneal chemotherapy (IP). To study the preventive effect of early active / passive motion combined with intermittent inflated pressure massage on VTE. Methods: from May 2015 to August 2016, 120 patients with peritoneal carcinoma from gastrointestinal and gynecological tumors were treated with CRS HIPEC. The risk of VTE was evaluated by Caprini thrombotic risk assessment model. All patients were treated with early active / passive limb movement and intermittent pneumatic massage. VTE related events were recorded and analyzed. Results: the median Carprini score of the patients was 12 ~ 10 ~ (16), all of them were very high risk group of VTE. During 3 months follow-up, only one patient developed deep venous thrombosis, which was cured by drug therapy. Conclusion: the risk of VTE is very high in patients with peritoneal carcinoma. The combination of active / passive exercise and intermittent pneumatic compression massage such as dorsalis pedis / metatarsal flexion and chest dilatation can effectively prevent VTE.
【作者单位】：武汉大学中南医院肿瘤科肿瘤生物学行为湖北省重点实验室湖北省肿瘤医学临床研究中心;首都医科大学附属北京世纪坛医院腹膜肿瘤外科;
【基金】：2013年湖北省医学领军人才培养工程项目(编号:[2013]4号) 教育部博士点基金(编号:20120141110042)资助~~
【分类号】：R730.5

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