108例胃肠道间质瘤患者复发转移危险因素分析

发布时间：2018-05-05 03:04

本文选题：胃肠道间质瘤 + 复发转移　；参考：《胃肠病学和肝病学杂志》2017年03期

【摘要】：目的探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)复发转移危险因素。方法回顾性分析108例经手术证实的GIST患者的临床资料,并分析影响其复发转移的危险因素。结果 108例患者4年累计复发转移率为29.63%,单因素分析显示肿瘤大小、核分裂象数、肿瘤原发部位、术后服用伊马替尼、Ki67指数与GIST复发转移有关(P0.05),多因素分析显示肿瘤大小、核分裂象数、肿瘤原发部位、术后服用伊马替尼是影响GIST复发转移的独立危险因素。结论肿瘤大小、核分裂象、肿瘤原发部位是GIST复发转移的独立危险因素,术后伊马替尼分子靶向治疗可明显降低GIST复发转移风险。
[Abstract]:Objective to investigate the risk factors of recurrence and metastasis of gastrointestinal stromal tumors (GIST). Methods the clinical data of 108 patients with GIST confirmed by operation were retrospectively analyzed and the risk factors affecting their recurrence and metastasis were analyzed. Results the cumulative recurrence and metastasis rate of 108 patients in 4 years was 29.63. Single factor analysis showed that tumor size, mitotic number, primary location of the tumor, postoperative use of imatinib Ki67 index and GIST recurrence and metastasis were related to P0.05, multivariate analysis showed tumor size. Mitotic number, primary site of tumor, postoperative administration of imatinib were independent risk factors for recurrence and metastasis of GIST. Conclusion tumor size, mitotic image and primary tumor site are independent risk factors for recurrence and metastasis of GIST. Imatinib molecular targeted therapy after operation can significantly reduce the risk of recurrence and metastasis of GIST.
【作者单位】：重庆医科大学附属第一医院消化内科;
【分类号】：R735

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