叉头框P1、白介素-6在结直肠腺癌中的表达及意义

发布时间：2018-05-05 13:04

  本文选题：结直肠癌 + FOXP1　； 参考：《山西医科大学》2017年硕士论文

【摘要】：目的:通过研究叉头框P1(forkhead box P1,FOXP1)及白介素-6(Interleukin-6,IL-6)在人结直肠腺癌组织中的表达及其与临床病理学参数间的关系,探讨二者在结直肠腺癌中的作用及二者间的相关性。方法:采用免疫组化法检测120例结直肠腺癌组织及20例癌旁组织中FOXP1及IL-6的表达,分析各指标与结直肠腺癌临床病理学参数间关系及FOXP1与IL-6的相关性。结果:(1)结直肠腺癌组织中FOXP1及IL-6的阳性表达率分别为68.3%和75.8%,癌旁组织中FOXP1及IL-6的阳性表达率分别为35%和20.0%。与癌旁组织相比,FOXP1及IL-6在结直肠腺癌组织中的表达明显增加。(2)FOXP1在高、中、低分化组中的表达率分别为:36.0%、69.4%、90.9%,随着分化程度下降,表达依次增加,χ2=19.881,p0.01;FOXP1在有淋巴结转移组中的表达率为80.9%,与无淋巴结转移组(30.8%)相比表达明显升高,χ2=24.325,p0.01;FOXP1在Ⅰ+Ⅱ期表达率为51.8%,明显低于Ⅲ+Ⅳ期表达率76.6%,χ2=8.059,p=0.007。FOXP1在结直肠腺癌中的表达增加与患者年龄、性别、发生部位差异无统计学意义(p0.05)。(3)IL-6在高、中、低分化组中的表达率分别为:64.0%、70.9%、93.9%,随着分化程度下降,表达依次增加,χ2=8.614,p=0.013;IL-6在淋巴结转移组中的表达率为81.9%,明显高于无淋巴结转移组53.8%,χ2=19.875,p0.01;IL-6在Ⅰ+Ⅱ期表达率为64.3%,Ⅲ+Ⅳ期与之相比,表达率(85.9%)显著增加,χ2=7.640,p=0.01。IL-6在结直肠腺癌中的表达增加与患者年龄、性别、发生部位无明显统计学差异(p0.05)。(4)FOXP1与IL-6蛋白表达呈正相关关系(r=0.453,p0.01)。结论:(1)FOXP1及IL-6的高表达可能是结直肠腺癌的促进因素。(2)FOXP1及IL-6高表达与结直肠癌的进展、分化程度及淋巴结转移相关,可能作为结直肠腺癌的有效预后标记物及临床治疗的靶点。(3)FOXP1与IL-6的表达呈现正相关。
[Abstract]:Objective: to investigate the expression of P1(forkhead box P1FXP1 and Interleukin-6IL-6 in human colorectal adenocarcinoma and their relationship with clinicopathological parameters, and to explore their roles in colorectal adenocarcinoma and the correlation between them. Methods: immunohistochemical method was used to detect the expression of FOXP1 and IL-6 in 120 cases of colorectal adenocarcinoma and 20 cases of paracancerous tissues. The relationship between each index and clinicopathological parameters of colorectal adenocarcinoma and the correlation between FOXP1 and IL-6 were analyzed. Results the positive expression rates of FOXP1 and IL-6 in colorectal adenocarcinoma tissues were 68.3% and 75.8%, respectively. The positive rates of FOXP1 and IL-6 in adjacent tissues were 35% and 20.0%, respectively. The expression rates of FOXP1 and IL-6 in colorectal adenocarcinoma tissues were significantly higher than those in paracancerous tissues. The expression rates of FOXP1 in high, middle and low differentiation groups were 36.0 and 69.4%, respectively, and decreased with the degree of differentiation. The expression of FOXP1 in the group with lymph node metastasis was 80.9, which was significantly higher than that in the group without lymph node metastasis. The expression rate of FOXP1 in stage 鈪，

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