肺癌患者血清NGAL的水平及意义

发布时间：2018-05-10 08:38

  本文选题：肺癌 + 中性粒细胞明胶酶相关脂质运载蛋白　； 参考：《郑州大学》2017年硕士论文

【摘要】：目的探讨肺癌患者血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)的水平变化及意义,以期有助于肺癌的早期诊断及治疗。方法选取2014年10月至2016年10月在郑州大学第五附属医院经病理确诊且是初诊未行放、化疗治疗的肺癌患者为研究对象,共入选肺癌患者112例(肺癌组);并选取同期在郑州大学第五附属医院体检中心体检的112例健康人(对照组)。记录所有受试者的一般资料及肺癌组患者的组织病理及免疫组化结果,并在空腹12h后采集所有受试者的静脉血样,应用酶联免疫吸附法测定肺癌组与健康对照组的血清NGAL水平。采用SPSS 19.0统计学软件进行相关分析,分别采用t检验、χ2检验、单因素方差分析等比较组间差异,然后采用多因素Logistic回归分析肺癌发生、发展及远处转移的危险因素。结果肺癌组血清NGAL水平高于对照组(P0.05);肺癌组吸烟指数(smoking index,SI)明显高于对照组(P0.01);不同性别、年龄、吸烟史间两组患者血清NGAL水平均无显著性差异;肺癌不同部位、大小、病理类型及有无区域淋巴结转移间,血清NGAL水平的差异均无统计学意义;低分化肺癌患者血清NGAL水平高于高分化肺癌患者,有远处转移的肺癌患者血清NGAL水平显著高于无远处转移者;Ⅳ期患者的血清NGAL水平均显著高于Ⅰ期+Ⅱ期;多因素回归分析显示,血清NGAL(OR=2.942,P=0.021)、吸烟指数(OR=8.610,P=0.013)与肺癌的发生有关,且血清NGAL(OR=5.603,P=0.035)与肺癌远处转移有关。结论1、NGAL在肺癌患者血清中高表达;2、NGAL与肺癌的发生有关,且NGAL与肺癌的分化程度、远处转移、临床分期有关,可在一定程度上反映肺癌的侵袭性、评估肺癌患者的预后。
[Abstract]:Objective to investigate the changes and significance of serum neutrophil gelatinase-associated lipocalin NGALs in patients with lung cancer in order to help the early diagnosis and treatment of lung cancer. Methods from October 2014 to October 2016, lung cancer patients who had been diagnosed pathologically and were treated with chemotherapy and without radiotherapy were selected as the study subjects, who were admitted to the Fifth affiliated Hospital of Zhengzhou University from October 2014 to October 2016. 112 patients with lung cancer (lung cancer group) and 112 healthy persons (control group) who were examined in the medical examination center of the Fifth affiliated Hospital of Zhengzhou University at the same time were selected. The general data of all subjects and the histopathological and immunohistochemical results of lung cancer patients were recorded. The venous blood samples of all subjects were collected 12 hours after an empty stomach. The serum NGAL levels in lung cancer group and healthy control group were measured by enzyme linked immunosorbent assay (Elisa). Correlation analysis was carried out with SPSS 19.0 software. T test, 蠂 2 test and univariate ANOVA were used to compare the differences between groups, and then multivariate Logistic regression analysis was used to analyze the risk factors of lung cancer occurrence, development and distant metastasis. Results Serum NGAL level in lung cancer group was higher than that in control group (P 0.05), smoking index in lung cancer group was significantly higher than that in control group (P 0.01), there was no significant difference in serum NGAL level between two groups with different sex, age, smoking history, different location and size of lung cancer. There was no significant difference in serum NGAL level between the pathological types and regional lymph node metastasis, and the serum NGAL level in poorly differentiated lung cancer patients was higher than that in well-differentiated lung cancer patients. The serum NGAL level in patients with distant metastasis was significantly higher than that in patients without distant metastasis, and the level of serum NGAL in patients with stage 鈪，

本文编号：1868613