人乳头瘤状病毒感染型别及多重感染与宫颈癌发病风险的关系研究

发布时间：2018-05-13 03:09

本文选题：宫颈癌 + 液基薄层细胞学检查(TCT)　；参考：《中华生殖与避孕杂志》2017年06期

【摘要】：目的分析研究人乳头瘤状病毒(HPV)感染型别与宫颈癌发病风险的关系。方法回顾性分析2015年1月—12月液基薄层细胞学检查(TCT)联合HPV DNA检查进行宫颈癌筛查后,再进行阴道镜下宫颈组织病理检查的患者临床资料。结合患者的人口学信息,分析比较单一HPV感染及多重HPV感染型别分别与宫颈癌发病风险,其中以阴道镜下宫颈组织病理检查结果为金标准。结果 2 195名患者的检查结果显示,年龄是宫颈癌发病风险之一,TCT检测结果为低度鳞状上皮内病变(LSIL)或高度鳞状上皮内病变(HSIL),易发高级别宫颈上皮内病变和浸润癌,单一感染与多重感染患者间宫颈癌发病风险没有统计学差异(P0.05),HPV16型的感染率较高,无论患者是否为单一与多重感染,HPV16型都为宫颈癌发病风险,其OR值为6.27。结论需要重视38岁以上妇女的宫颈癌筛查,随着宫颈病变级别增加,HPV单一感染率与多重感染率无统计学差异,且宫颈鳞癌HPV感染倾向于单一高危型HPV16型。
[Abstract]:Objective to study the relationship between the type of HPV infection and the risk of cervical cancer. Methods the clinical data of cervical cancer screening by liquid based thin layer cytology (TCTT) combined with HPV DNA from January to December 2015 were analyzed retrospectively. Combined with the demographic information of the patients, the types of single HPV infection and multiple HPV infection were analyzed and compared with the risk of cervical cancer. The results of pathological examination of cervical tissue under colposcopy were regarded as the golden standard. Results the results of 2 195 patients showed that age was one of the risk factors of cervical cancer. The results of TCT were low grade squamous intraepithelial lesion (LSIL) or high grade squamous intraepithelial lesion (HSILL), and were prone to high grade cervical intraepithelial lesion and invasive carcinoma. There was no significant difference in the risk of cervical cancer between patients with single infection and multiple infection. The infection rate of HPV16 was higher than that of single infection and multiple infection, and the OR value was 6.27. Conclusion it is necessary to pay attention to the screening of cervical cancer in women over 38 years of age. There is no significant difference between single infection rate and multiple infection rate with the increase of cervical lesion grade, and the HPV infection of cervical squamous cell carcinoma tends to be a single high-risk type of HPV16.
【作者单位】：上海市长宁区妇幼保健院;上海交通大学公共卫生学院;
【基金】：上海市长宁区卫计委医学重点专科(妇科微创重点专科)~~
【分类号】：R737.33

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