PD-L1和APE1在早期宫颈鳞癌中的表达及临床意义

发布时间：2018-05-16 00:01

本文选题：早期宫颈鳞癌 + 程序性死亡配体-　；参考：《第三军医大学学报》2017年01期

【摘要】：目的探讨早期宫颈鳞癌组织中程序性死亡配体-1(programmed death ligand-1,PD-L1)和脱嘌呤/脱嘧啶内切核酸酶1(apurinic/apyrimidinic endonuclease1,APE1)的表达与临床特征及预后的关系。方法采用免疫组织化学的方法(IHC)检测PD-L1和APE1蛋白在64例早期宫颈鳞癌组织中的表达,分析PD-L1、APE1表达以及两者共表达与早期宫颈癌临床特征的关系;采用Spearman等级相关分析检测APE1与PD-L1表达的相关性,Kaplan-Meier法分析早期宫颈鳞癌患者中APE1与PD-L1的表达与术后生存的关系,Cox回归模型分析早期宫颈鳞癌患者预后的危险因素。结果早期宫颈癌患者APE1和PD-L1蛋白表达阳性率分别为70.31%和67.18%。PD-L1的表达与分期、淋巴结转移有显著相关性(P0.05),而APE1的表达仅与淋巴结转移密切相关(P=0.038)。另外,APE1与PD-L1的表达正相关(r2=0.347,P=0.005),且两者共表达与淋巴结转移相关,其术后生存期比单一阳性表达的宫颈癌患者明显缩短(P0.05)。多因素COX回归模型结果显示,APE1的表达和淋巴结转移是影响早期宫颈鳞癌预后的独立危险因素,危险度分别为16.187(P=0.01)和27.340(P0.001)。结论PD-L1和APE1表达的联合检测对早期宫颈鳞癌预后评估具有潜在的临床价值。
[Abstract]:Objective to investigate the relationship between the expression of programmed death ligands (-1C) and 1(apurinic/apyrimidinic endonuclease (1(apurinic/apyrimidinic endonuclease 1) and prognosis in early squamous cell carcinoma of cervix. Methods Immunohistochemical method was used to detect the expression of PD-L1 and APE1 protein in 64 cases of early cervical squamous cell carcinoma. The correlation between APE1 and PD-L1 expression was detected by Spearman rank correlation analysis. Kaplan-Meier method was used to analyze the relationship between the expression of APE1 and PD-L1 and postoperative survival in patients with early cervical squamous cell carcinoma. Cox regression model was used to analyze the prognostic factors of early squamous cell carcinoma of cervix. Results the positive rates of APE1 and PD-L1 were 70.31% and 70.31%, respectively. The expression of 67.18%.PD-L1 was significantly correlated with lymph node metastasis (P0.05), while the expression of APE1 was only closely related to lymph node metastasis (P0.038). In addition, there was a positive correlation between the expression of APE1 and PD-L1, and the coexpression of APE1 and PD-L1 was correlated with lymph node metastasis. The postoperative survival time of patients with single positive expression of APE1 was significantly shorter than that of cervical cancer patients with single positive expression. The results of multivariate COX regression model showed that the expression of APE1 and lymph node metastasis were independent risk factors for the prognosis of early squamous cell carcinoma of the cervix. Conclusion the combined detection of PD-L1 and APE1 expression has potential clinical value in early stage squamous cell carcinoma of cervix.
【作者单位】：第三军医大学大坪医院野战外科研究所肿瘤中心;
【分类号】：R737.33

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