血清维生素E和胡萝卜素β以及维生素A与原发性肝癌死亡率的相关性研究

发布时间：2018-05-16 15:12

本文选题：肝肿瘤 + 维生素E　；参考：《中国全科医学》2017年20期

【摘要】：目的探讨血清3种维生素(维生素E、胡萝卜素β以及维生素A)参与调控氧化应激损伤与原发性肝癌患者死亡率之间的相关性。方法选取2010年1月—2013年1月于武汉科技大学附属天佑医院就诊的初发原发性肝癌术后患者198例。随访3年,根据随访结束时生存结果,分为存活组(n=101)和死亡组(n=97)。分别于术后1个月和术后3个月检测血清维生素E、胡萝卜素β、维生素A水平和氧化应激指标,包括总抗氧化态(TAS)、总氧化态(TOS)和氧化应激指数(OSI)以及其变化差值。结果死亡组术后3个月维生素E水平、维生素E变化差值、维生素A变化差值均低于存活组(P0.05)。死亡组术后3个月TAS水平、TAS变化差值、TOS变化差值、OSI变化差值均低于存活组,术后3个月TOS水平、OSI高于存活组(P0.05)。术后3个月维生素E水平和维生素E变化差值预测肝癌术后3年死亡事件发生的受试者工作特征曲线下面积(AUC)分别为0.798[95%CI(0.716,0.894)]、0.894[95%CI(0.735,0.934)]。术后3个月维生素E水平与术后3个月TAS水平呈正相关(r=0.521,P0.05),与死亡率呈负相关(r=-0.611,P0.05);维生素E变化差值与死亡率呈负相关(r=-0.653,P0.05)。多因素Logistic回归分析结果显示,术后3个月维生素E10.1μmol/L[OR=0.78,95%CI(0.40,0.98)]和维生素E变化差值0.6μmol/L[OR=0.89,95%CI(0.49,0.99)]是肝癌术后3年死亡事件发生的独立影响因素(P0.05)。结论原发性肝癌患者术后3个月维生素E水平是肝癌术后3年死亡事件发生的潜在预测因子。
[Abstract]:Objective to investigate the relationship between serum vitamin E, carotene 尾 and vitamin A in regulating oxidative stress injury and mortality in patients with primary liver cancer. Methods from January 2010 to January 2013, 198 patients with primary hepatocellular carcinoma were selected from Tianyou Hospital of Wuhan University of Science and Technology. According to the survival results at the end of follow-up, the patients were divided into two groups: survival group (n = 101) and death group (n = 97). The levels of serum vitamin E, carotene 尾, vitamin A and oxidative stress indexes, including total antioxidant status, total oxidative stress index (TOS) and oxidative stress index (OSI), were measured 1 month after operation and 3 months after operation. Results the levels of vitamin E, the difference of vitamin E and the difference of vitamin A in the death group were lower than those in the survival group 3 months after operation (P 0.05). Three months after operation, the level of TAS in the death group was lower than that in the survival group. The level of TOS in the death group was higher than that in the survival group (P 0.05). The difference between vitamin E level and vitamin E changes in 3 months after operation was 0.798 [95 CI 0.716 0. 894] 0. 894 [95 CI 0. 735 0. 934] in predicting the area under the operating characteristic curve of the subjects who died 3 years after operation of liver cancer. There was a positive correlation between vitamin E level and TAS level 3 months after operation, and a negative correlation between vitamin E level and mortality, and a negative correlation between vitamin E level and mortality. The results of multivariate Logistic regression analysis showed that vitamin E 10.1 渭 mol/L [OR0.78C95 CI 0.40 0.98] and vitamin E variation difference 0.6 渭 mol/L (0.89 ~ 95CI0.99) were independent influencing factors of mortality in 3 years after operation of hepatocellular carcinoma (P0.05). Conclusion Vitamin E level in patients with primary liver cancer is a potential predictor of mortality in 3 years after operation.
【作者单位】：武汉科技大学附属天佑医院肿瘤科;武汉科技大学附属天佑医院检验科;
【分类号】：R735.7

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