生血宝合剂治疗非小细胞肺癌患者化疗后白细胞减少症210例多中心随机、双盲对照临床研究

发布时间：2018-05-16 21:14

  本文选题：非小细胞肺癌 + 化疗　； 参考：《中医杂志》2017年09期

【摘要】：目的评价生血宝合剂治疗非小细胞肺癌化疗引起的白细胞减少症的有效性。方法采用随机双盲、平行对照、多中心临床试验的方法,将非小细胞肺癌化疗后白细胞减少症患者随机分为治疗组210例,对照组70例。在下一次化疗前1天开始治疗组予生血宝合剂,每次15 ml,每日3次;对照组给予安多霖胶囊,每次4粒,每日3次。两组疗程均为3周。观察两组患者治疗前后外周血白细胞计数变化及分级、中医证候疗效及单项症状疗效、Karnofsky评分。结果两组治疗后外周血白细胞数计数均高于治疗前(P0.05),且治疗组治疗后及治疗前后差值高于对照组(P0.05)。治疗组治疗后Ⅱ度、Ⅲ度及Ⅳ度白细胞减少总发生率(2.85%)低于对照组(4.29%)(P0.05)。治疗组中医证候疗效总有效率为88.1%,对照组为60.00%,治疗组优于对照组(P0.05)。治疗组神疲乏力、头晕目眩、心悸气短、烦躁不安单项症状疗效均优于对照组(P0.05)。结论生血宝合剂能有效防治非小细胞肺癌化疗引起的白细胞减少症,改善化疗后患者癌因性疲乏。
[Abstract]:Objective to evaluate the efficacy of Shengxue Bao mixture in the treatment of leukopenia induced by chemotherapy in non-small cell lung cancer. Methods the patients with leukopenia after chemotherapy were randomly divided into treatment group (n = 210) and control group (n = 70). One day before the next chemotherapy, the treatment group was treated with Shengxue Bao mixture, 15 ml per time, 3 times a day, while the control group was given 4 capsules of Anduolin capsule, 3 times a day. The course of treatment was 3 weeks in both groups. The changes and grades of peripheral blood leukocyte count, the curative effect of TCM syndromes and single symptom were observed before and after treatment and Karnofsky score. Results after treatment, the white blood cell count in both groups was higher than that before treatment, and the difference between the treatment group and the control group was higher than that in the control group after treatment and before and after treatment. The total incidence of leukopenia in the treatment group (鈪，

本文编号：1898405