胸腔镜手术对小儿纵隔肿瘤术后感染及疼痛应激相关血液指标的影响研究

发布时间：2018-05-17 06:02

本文选题：胸腔镜手术 + 小儿纵隔肿瘤　；参考：《中华医院感染学杂志》2017年04期

【摘要】：目的研究胸腔镜手术对小儿纵隔肿瘤术后感染及疼痛应激相关血液指标的影响,以了解该类手术的临床应用价值。方法选取2012年1月-2016年1月于医院进行手术治疗的纵隔肿瘤患儿64例为研究对象,将其随机分为对照组和观察组,每组各32例,对照组患儿进行传统开胸手术治疗,观察组患儿则进行胸腔镜手术治疗,统计比较两组患儿的术后感染率、术前及术后疼痛应激相关血液指标。结果观察组患儿术后的感染率为3.13%,明显低于对照组12.50%;术前两组手术患儿致痛介质5-HT、PGE2、BK及NPY血清表达水平比较,差异无统计学意义,而术后12与24h观察组手术患儿致痛介质5-HT、PGE2、BK及NPY血清表达水平均低于对照组,差异有统计学意义(P0.05);术前两组手术患儿其他疼痛应激指标NO、IL-1β及IL-6血清表达水平比较,差异无统计学意义,而术后12与24h观察组手术患儿其他疼痛应激指标NO、IL-1β及IL-6血清表达水平均低于对照组,差异有统计学意义(P0.05)。结论胸腔镜手术对小儿纵隔肿瘤术后感染及疼痛应激相关血液指标的控制效果较好,因此该术式更为适用于纵隔肿瘤患儿,临床应用价值较高。
[Abstract]:Objective to study the effect of thoracoscopic surgery on postoperative infection and pain stress in children with mediastinal tumor. Methods from January 2012 to January 2016, 64 children with mediastinal tumor were randomly divided into control group and observation group with 32 cases in each group. The patients in the observation group were treated with thoracoscopic surgery, and the postoperative infection rate, blood indexes related to pain stress before and after operation were compared statistically between the two groups. Results the postoperative infection rate of children in the observation group was 3.13, which was significantly lower than that in the control group 12.50. There was no significant difference in the expression of 5-HTPGE2BK and NPY between the two groups before operation. However, the serum levels of 5-HTG PGE2BK and NPY in the observation group 12 and 24 hours after operation were lower than those in the control group, the difference was statistically significant (P 0.05), and the serum levels of NO-IL-1 尾 and IL-6 were compared between the two groups before operation. There was no significant difference between the two groups, but the serum levels of NON-IL-1 尾 and IL-6 in the observation group 12 and 24 hours after operation were lower than those in the control group, and the difference was statistically significant (P 0.05). Conclusion the effect of thoracoscopic surgery on blood indexes related to infection and pain stress in children with mediastinal neoplasms is better, so it is more suitable for children with mediastinal tumors and has higher clinical application value.
【作者单位】：福建医科大学附属第一医院小儿外科;
【分类号】：R726.1

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