叉头框M1在结直肠癌中的表达及临床意义

发布时间：2018-05-18 20:52

本文选题：结直肠肿瘤 + 叉头框M　；参考：《临床与实验病理学杂志》2017年08期

【摘要】：目的探讨叉头框M1(FOXM1)在结直肠癌中的表达及与临床病理特征、预后的关系。方法采用免疫组化SP法检测297例结直肠癌组织和80例对应癌旁正常组织中FOXM1的表达;Western blot法检测20例新鲜结直肠癌组织及对应癌旁组织中FOXM1的表达。结果 FOXM1在结直肠癌组织中的阳性率(70.97%)显著高于癌旁组织(17.50%,P0.01);FOXM1表达与结直肠癌浸润深度、淋巴结转移、脉管内癌栓转移、远处转移和TNM分期有关(P0.05);与患者年龄、性别、肿瘤部位、大小、分化程度、CEA、CA199等无关(P0.05)。结直肠癌组织中FOXM1蛋白相对表达量(0.855±0.063)明显高于相应癌旁组织(0.150±0.041,P0.01)。FOXM1阳性患者的3年生存率明显低于阴性患者(P0.01),且FOXM1为结直肠癌预后的独立性危险因素。结论 FOXM1蛋白在结直肠癌组织中过表达,且与患者临床病理特征、预后等因素有关,可能在结直肠癌的发生、转移等过程中起重要作用,有望成为结直肠癌新的肿瘤标志物和潜在的治疗靶点。
[Abstract]:Objective to investigate the expression of forked frame M1FXM1 in colorectal cancer and its relationship with clinicopathological features and prognosis. Methods Immunohistochemical SP method was used to detect the expression of FOXM1 in 297 cases of colorectal carcinoma and 80 cases of adjacent normal tissues. Western blot method was used to detect the expression of FOXM1 in 20 cases of fresh colorectal carcinoma and 20 cases of adjacent tissues. Results the positive rate of FOXM1 in colorectal cancer tissues was significantly higher than that in paracancerous tissues (P 0.01). The expression of FOXM1 was associated with the depth of invasion, lymph node metastasis, intravascular tumor thrombus metastasis, distant metastasis and TNM staging in colorectal carcinoma, and was associated with age, sex and tumor location. The size and differentiation of CEA CA199 were not related to P0.05. The relative expression of FOXM1 protein in colorectal cancer tissues was 0.855 卤0.063), which was significantly higher than that in the corresponding paracancerous tissues (0.150 卤0.041). The 3-year survival rate of patients with positive FOXM1 protein was significantly lower than that of negative patients. FOXM1 was the independent risk factor for the prognosis of colorectal cancer. Conclusion the overexpression of FOXM1 protein in colorectal carcinoma may play an important role in the occurrence and metastasis of colorectal cancer, and may be related to the clinicopathological features and prognosis of colorectal cancer. It is expected to be a new tumor marker and potential therapeutic target for colorectal cancer.
【作者单位】：安徽医科大学第一附属医院胃肠外科;安徽医科大学第一附属医院病理科;
【基金】：安徽省省级质量工程项目(2016jxtd061) 安徽医科大学第一附属医院2015度新技术项目(2-22) 安徽医科大学第一附属医院2014后备人才项(20148)
【分类号】：R735.34

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