乳腺癌多原发癌的临床病理特征及预后分析

发布时间：2018-05-19 03:35

本文选题：多原发癌 + 乳腺癌　；参考：《中国肿瘤临床》2017年05期

【摘要】：目的:探讨乳腺癌多原发癌(multiple primary cancers,MPCs)患者的临床病理特征及预后因素。方法:回顾性分析2005年1月至2015年12月天津医科大学肿瘤医院收治的226例乳腺癌MPCs患者的临床病理资料,应用单因素及多因素分析方法分析其临床病理学特征及影响预后的因素。结果:226例中74例(32.7%)为同时型MPCs,152例(67.3%)为异时型MPCs。在第二原发恶性肿瘤中甲状腺癌最常见,为90例。患者的中位随访时间为84.75(4.1~384.5)个月,226例患者的3年及5年总生存率分别为91.7%和82.9%。乳腺癌MPCs患者的病理特征以肿瘤负荷大(65.5%vs.34.5%,P=0.005)和ER受体阳性(76.1%vs.23.9%,P=0.046)多见,异时型MPCs更倾向于高龄人群(62.4%vs.37.6%,P0.001)。无淋巴结转移(95%CI:0.341~0.932,P=0.025)和异时型MPCs(95%CI:0.033~0.220,P0.001)患者预后佳。结论:甲状腺是最常见的第二原发肿瘤,肿瘤负荷大及ER受体阳性患者易发生乳腺癌MPCs,高龄患者易患异时型MPCs,有无淋巴结转移和MPCs的类型是患者预后的独立影响因素。
[Abstract]:Objective: to investigate the clinicopathological features and prognostic factors of multiple primary carcinomas of breast cancer. Methods: the clinicopathological data of 226 MPCs patients with breast cancer admitted to Tianjin Medical University Oncology Hospital from January 2005 to December 2015 were retrospectively analyzed. The clinicopathological features and prognostic factors were analyzed by univariate and multivariate analysis. Results among 226 cases, 74 cases (32. 7%) were of simultaneous MPCsm (152 cases) and 67.3%) were heterochronous MPCs. Thyroid carcinoma is the most common cancer in the second primary malignant tumor, 90 cases. The median follow-up time was 84.75 / 4.1 / 384.5) the 3-year and 5-year overall survival rates of 226 patients were 91.7% and 82.9%, respectively. The histopathological features of MPCs patients with breast cancer were more than 65.5vs.34.5v and 76.1vs.23.9P0.046), and the abnormal MPCs tended to be 62.4vs.37.6cu (P 0.001) in the elderly. The pathological features of the patients with breast cancer were as follows: 65.5vs.34.5v. 005) and 76.1vs.23.9p0.046), and the abnormal type of MPCs was more likely to be 62.4vs.37.6m. The prognosis of the patients without lymph node metastasis was better than that of the patients without lymph node metastasis (I: 0.341n 0.932 P0.025) and heterotypic MPCs1 95CI: 0.033 0.220 P0.001). Conclusion: thyroid gland is the second most common primary tumor. Breast cancer is prone to MPCs in patients with high tumor load and ER receptor positive. MPCs in elderly patients are prone to develop heterochronous MPCs. Lymph node metastasis and MPCs are independent prognostic factors.
【作者单位】：天津医科大学肿瘤医院乳腺肿瘤内科国家肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室;
【基金】：国家科技支撑计划课题(编号:2015BAI12B15)资助~~
【分类号】：R737.9

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