非小细胞肺癌脑转移患者接受一代表皮生长因子受体酪氨酸激酶抑制剂治疗的临床研究

发布时间：2018-05-22 08:13

本文选题：肺肿瘤 + 脑转移　；参考：《中国肺癌杂志》2017年02期

【摘要】：背景与目的非小细胞肺癌(non-small cell lung cancer,NSCLC)脑转移患者接受一代表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)的生存数据及影响因素未完全阐明。本研究对存在脑转移的NSCLC患者的生存数据进行分析,以期为指导临床实践提供一定的研究证据。方法回顾性收集上海交通大学附属胸科医院2012年-2013年确诊肺癌脑转移并接受一代EGFRTKIs治疗的病例。采用Kaplan-Meier单因素、Cox多因素分析方法,探讨NSCLC脑转移患者接受EGFR-TKIs的生存情况及影响因素。结果总体人群中位无进展生存时间(progression-free survival,PFS)为10.0个月(95%CI:8.3-11.7),中位生存时间(overall survival,OS)为28.0个月(95%CI:22.9-33.1)。病理组织类型、肿瘤分化程度分别是患者接受EGFR-TKIs后PFS、OS的独立影响因素(P分别为0.001、0.050)。结论 NSCLC脑转移患者接受一代EGFR-TKIs具有良好的疗效,腺癌亚型患者的PFS长于非腺癌患者,其他肿瘤分化程度患者的OS长于肿瘤低分化患者。
[Abstract]:Background & objective the survival data and the influencing factors of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TK Isa) in patients with brain metastasis of non-small cell lung cancer from non-small cell lung cancer have not been fully elucidated. In this study, survival data of NSCLC patients with brain metastasis were analyzed in order to provide evidence for clinical practice. Methods cases of brain metastases from lung cancer diagnosed by chest Hospital affiliated to Shanghai Jiaotong University from 2012 to 2013 were retrospectively collected and treated with a generation of EGFRTKIs. Kaplan-Meier univariate Cox multivariate analysis was used to investigate the survival and influencing factors of EGFR-TKIs in patients with brain metastasis of NSCLC. Results the median progression-free survival time (PFSs) was 10.0 months or 95 months (CI: 8.3-11.7m), and the median survival time was 28.0 months (95 CI: 22.9-33.1). Histopathologic type and tumor differentiation degree were the independent factors influencing the EGFR-TKIs after EGFR-TKIs (P = 0.001 0. 050). Conclusion NSCLC brain metastases with a generation of EGFR-TKIs has a good effect. PFS in patients with adenocarcinoma subtype is longer than that in non-adenocarcinoma patients, and OS in patients with other tumor differentiation is longer than that in patients with low tumor differentiation.
【作者单位】：上海交通大学附属胸科医院呼吸内科;上海交通大学医学院附属同仁医院呼吸内科;
【基金】：国家自然科学基金面上项目(No.81472175) 上海市卫生和计划生育委员会重点项目(No.20134007)资助~~
【分类号】：R734.2

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