甲氧氯普胺与阿瑞匹坦在预防高致吐性化疗致延迟性恶心呕吐的疗效及安全性比较

发布时间：2018-05-22 11:50

本文选题：甲氧氯普胺 + 阿瑞匹坦　；参考：《广东医学》2017年09期

【摘要】：目的比较甲氧氯普胺(MPD)与阿瑞匹坦(APD)在联合地塞米松基础上预防高致吐性化疗(HEC)引起的延迟性恶心呕吐的有效性和安全性。方法将接受HEC的实体瘤患者随机分为MPD组(30例)和APD组(31例),MPD组的止吐方案为MPD 20 mg,2次/d(d2~4);帕洛诺司琼0.25 mg(d1);地塞米松20 mg(d1),8 mg,2次/d(d2~4)。APD组的止吐方案为APD 125 mg(d1),80 mg(d2~3);帕洛诺司琼0.25 mg(d1);地塞米松12 mg(d1),8 mg(d2~4)。主要研究终点是延迟期(化疗后24~120 h)内获得完全缓解(定义为无呕吐及未使用解救性止吐药物)的患者百分比(CRR),次要研究终点是不良反应发生率。结果 MPD组与APD组在延迟期恶心呕吐的CRR分别为83.3%(25/30)和80.6%(25/31),差异无统计学意义(P0.05)。两组主要不良反应为便秘、乏力及呃逆,不良反应发生率差异无统计学意义(P0.05),患者均可以耐受。结论 MPD联合帕洛诺司琼、地塞米松的止吐方案与标准的三联止吐方案(APD、帕洛诺司琼及地塞米松)相比,在HEC中具有相似的疗效及安全性。
[Abstract]:Objective to compare the efficacy and safety of metoclopramide (MPD) and aripitan (APD) combined with dexamethasone in the prevention of delayed nausea and vomiting induced by hyperemetic chemotherapy. Methods Thirty patients with solid tumor receiving HEC were randomly divided into MPD group (n = 30) and APD group (n = 31). The antiemetic regimen in the APD group was as follows: MPD 20 mg / d 2 / d 2X; paronosetron 0.25 mg / d 1; dexamethasone 20 mg / d 1 / 8 mg / L / 2 / d 2 / d 4. APD group: APD 125 mg / d ~ (1 / d) 80 mg / d ~ (2) D ~ (2); Qiong 0.25 mg / d ~ (-1); dexamethasone 12 mg / d ~ (-1) ~ (8 mg / d ~ (2) ~ (4). The main end point of the study was the percentage of patients with complete remission (defined as no vomiting and no use of rescue antiemetic drugs) during the delayed period (24 to 120 hours after chemotherapy), and the secondary endpoint was the incidence of adverse reactions. Results the CRR of MPD group and APD group in delayed nausea and vomiting were 83.3 / 30 and 80.625 / 31, respectively. There was no significant difference between them (P 0.05). The main adverse reactions of the two groups were constipation, fatigue and hiccup. There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion MPD combined with paronosetron and dexamethasone has a similar efficacy and safety in HEC compared with standard triple antiemetic regimen (APD, Palonosetron and dexamethasone).
【作者单位】：南方医科大学广州临床医学院;广州军区广州总医院肿瘤科;
【基金】：国家自然科学基金资助项目(编号:81172225,81472172)
【分类号】：R730.53

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