肝动脉化疗栓塞术治疗原发性肝细胞癌预后影响因素分析

发布时间：2018-05-23 23:06

本文选题：癌 + 肝细胞　；参考：《中国介入影像与治疗学》2017年12期

【摘要】：目的分析肝动脉化疗栓塞术(TACE)治疗原发性肝细胞癌(HCC)的预后影响因素。方法回顾性分析326例接受TACE治疗的HCC患者的资料。采用Kaplan-Meier法计算患者1、2、3年累积生存率,分别以Log-rank检验及Cox比例风险模型进行预后相关单因素及多因素分析。结果患者1、2、3年累积生存率分别为73.90%、40.20%、22.20%,中位生存期21个月。单因素分析显示,甲胎蛋白(AFP)、γ-谷氨酰转肽酶(GGT)、肿瘤最大径、肿瘤数目、肝功能Child-Pugh分级、巴塞罗那临床肝癌(BCLC)分期、门静脉癌栓、动静脉瘘、远处转移为影响HCC患者预后的相关因素(P均0.05)。多因素分析显示,AFP、GGT、肿瘤最大径、肿瘤数目、BCLC分期、动静脉瘘为HCC患者预后的独立影响因素(P均0.05)。结论影响TACE治疗HCC患者预后的独立因素包括AFP、GGT、肿瘤最大径、肿瘤数目、BCLC分期及动静脉瘘。
[Abstract]:Objective to analyze the prognostic factors of hepatic arterial chemoembolization (TACEE) for primary hepatocellular carcinoma (HCC). Methods the data of 326 HCC patients treated with TACE were analyzed retrospectively. The 1- and 3-year cumulative survival rates were calculated by Kaplan-Meier method. The prognostic factors were analyzed by Log-rank test and Cox proportional risk model. Results the cumulative survival rates of 1 and 3 years were 73.90% and 40.20%, respectively. The median survival time was 21 months. Univariate analysis showed that AFP, 纬 -glutamyl transpeptidase (GGT), tumor maximum diameter, tumor number, liver function Child-Pugh grade, clinical liver cancer staging, portal vein tumor thrombus, arteriovenous fistula, and so on. Distant metastasis was associated with prognosis in patients with HCC (P < 0.05). Multivariate analysis showed that AFP G GTT, tumor maximum diameter, tumor number and BCLC staging, arteriovenous fistula were all independent prognostic factors of HCC patients (P < 0.05). Conclusion the independent factors influencing the prognosis of HCC patients with TACE include AFP-G GTT, tumor maximum diameter, tumor number, BCLC stage and arteriovenous fistula.
【作者单位】：郑州大学附属肿瘤医院河南省肿瘤医院放射介入科;
【基金】：2017年河南省医学科技攻关项目(201701032)
【分类号】：R735.7

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