结直肠癌患者膳食纤维摄入情况对肠道菌群的影响

发布时间：2018-05-24 12:13

本文选题：结直肠癌 + 膳食纤维　；参考：《中国老年学杂志》2017年15期

【摘要】：目的探讨结直肠癌患者膳食纤维的摄入对肠道菌群的影响。方法 280例结直肠癌患者为研究对象,并选取参与体检的290例健康人群作为对照组;采用自行设计的调查问卷调查受试者基本情况及膳食纤维摄入情况。收集两组研究对象粪便,提取粪便DNA,采用荧光定量PCR方法测定受试者肠道菌群水平,分析肠道菌群与大肠癌发病的相关性。结果除谷类与海鲜,结直肠癌组蔬菜、水果、豆类的摄入均明显低于对照组(均P0.05),肉类的摄入明显高于对照组(P0.05),总膳食纤维的摄入明显低于对照组研究对象(P0.05)。结直肠癌患者乳酸杆菌、双歧杆菌明显减少(P0.05),大肠杆菌、粪肠球菌、屎肠球菌、拟杆菌属、脆弱拟杆菌、单形拟杆菌、多形拟杆菌、吉氏拟杆菌、普通拟杆菌、梭杆菌属、梭菌属、肉毒梭菌、艰难梭菌明显增多(均P0.05)。在结直肠癌组中,除脆弱拟杆菌、单形拟杆菌外,在对照组中,除吉氏拟杆菌外高膳食纤维亚组与低膳食纤维亚组的各菌群水平均有差异(均P0.05);在高膳食纤维亚组,结直肠癌患者与对照组研究对象各菌群水平均有差异(均P0.05)。结直肠癌组与对照组乳酸杆菌、双歧杆菌与膳食纤维水平呈正相关(均P0.05),粪肠球菌、屎肠球菌、普通拟杆菌、梭杆菌属、梭菌属、肉毒梭菌、艰难梭菌与膳食纤维水平呈负相关(均P0.05)。结论结直肠癌患者膳食纤维的摄入情况影响肠道菌群水平。
[Abstract]:Objective to investigate the effect of dietary fiber intake on intestinal flora in colorectal cancer patients. Methods 280 patients with colorectal cancer and 290 healthy people were selected as control group, and the basic status of subjects and dietary fiber intake were investigated by self-designed questionnaire. The feces of two groups of subjects were collected and the fecal DNA was extracted. The levels of intestinal microflora were measured by fluorescence quantitative PCR method. The correlation between intestinal flora and the incidence of colorectal cancer was analyzed. Results except cereals and seafood, the intake of vegetables, fruits and legumes in colorectal cancer group was significantly lower than that in control group (P 0.05), the intake of meat was significantly higher than that of control group (P 0.05), and the total dietary fiber intake was significantly lower than that of control group (P 0.05). Lactobacillus, Bifidobacterium, Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Bacteroides fragilis, Bacteroides monomoides, Bacteroides polymorphic, Bacteroides gibbergii, Bacteroides vulgaris, Clostridium sp. Clostridium, Clostridium botulinum, Clostridium difficult increased significantly (P 0.05). In colorectal cancer group, in addition to Bacteroides fragilis and Bacteroides simplex, in the control group, there were significant differences between the high dietary fiber subgroup and the low dietary fiber subgroup (all P 0.05; in the high dietary fiber subgroup, P < 0.05), in the high dietary fiber subgroup, there were significant differences between the high dietary fiber subgroup and the low dietary fiber subgroup (P < 0.05). There were significant differences between the patients with colorectal cancer and those in the control group (P 0.05). There was a positive correlation between Lactobacillus, Bifidobacterium and dietary fiber levels in colorectal cancer group and control group (all P 0.05, Enterococcus faecalis, Enterococcus faecium, Bacteroides vulgaris, Clostridium, Clostridium, Clostridium, Clostridium botulinum). There was a negative correlation between Clostridium difficulty and dietary fiber level (all P 0.05). Conclusion the dietary fiber intake of colorectal cancer patients affects the intestinal flora level.
【作者单位】：武汉市中心医院胃肠外科;
【分类号】：R735.34

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