化疗期间心电图异常对蒽环类药物引起乳腺浸润性导管癌患者慢性心脏毒性的预测价值

发布时间：2018-05-25 13:58

本文选题：心电描记术 + 蒽环类　；参考：《中国全科医学》2017年09期

【摘要】：目的研究化疗期间心电图异常对蒽环类药物引起乳腺浸润性导管癌患者慢性心脏毒性的预测价值。方法收集郑州大学第二附属医院乳腺外科2013年5月—2015年5月收治的经病理检查确诊为乳腺浸润性导管癌患者123例。根据随访期间是否发生心脏毒性分为心脏毒性组21例和无心脏毒性组102例。观察两组心电图检查结果,分析乳腺浸润性导管癌化疗后发生慢性心脏毒性的影响因素。结果两组年龄比较,差异有统计学意义(P0.05);心脏毒性组心电图异常、ST-T段改变、T波异常发生率高于非心脏毒性组(P0.05);心脏毒性组心电图异常次数多于非心脏毒性组(P0.05)。多因素Logistic回归分析显示,年龄、心电图异常次数、ST-T段改变、T波异常是乳腺浸润性导管癌化疗后慢性心脏毒性的影响因素(P0.05)。结论女性乳腺浸润性导管癌的年龄、化疗期间心电图异常与慢性心脏毒性发生有一定相关性,对早期预防和治疗化疗引起的慢性心脏毒性有重要的临床指导意义。
[Abstract]:Objective to study the predictive value of abnormal ECG during chemotherapy for chronic cardiac toxicity in patients with invasive ductal carcinoma of breast induced by anthracyclines. Methods 123 patients with invasive ductal carcinoma of breast diagnosed by pathological examination from May 2013 to May 2015 in the second affiliated Hospital of Zhengzhou University were collected. According to whether or not cardiac toxicity occurred during follow-up period, 21 patients were divided into two groups: cardiac toxicity group (n = 21) and no cardiac toxicity group (n = 102). The results of electrocardiogram (ECG) in two groups were observed and the influencing factors of chronic cardiac toxicity after chemotherapy for invasive ductal carcinoma of breast were analyzed. Results there was significant difference between the two groups in age, the incidence of abnormal T wave in ECG abnormal ST-T segment in cardiotoxicity group was higher than that in non-cardiotoxic group, and the frequency of abnormal ECG in cardiotoxicity group was more than that in non-cardiotoxic group. Multivariate Logistic regression analysis showed that age and abnormal frequency of electrocardiogram (ECG) and abnormal ST-T segment were the influencing factors of chronic cardiotoxicity after chemotherapy for invasive ductal carcinoma of breast (P 0.05). Conclusion the age of female breast invasive ductal carcinoma, the abnormal ECG during chemotherapy and the occurrence of chronic cardiac toxicity are related to the occurrence of chronic cardiac toxicity, which has important clinical significance for early prevention and treatment of chronic cardiac toxicity caused by chemotherapy.
【作者单位】：郑州大学第二附属医院乳腺外科;
【分类号】：R737.9

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