开郁化痰法联合TP方案治疗中晚期食管癌的临床疗效观察

发布时间：2018-05-26 03:16

本文选题：开郁化痰法 + 中晚期食管鳞癌　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察开郁化痰法联合TP方案治疗中晚期食管癌的临床疗效观察。方法:将80例痰气交阻型中晚期食管鳞癌患者,随机分为治疗组和对照组各40例。治疗组采取开郁化痰法联合"TP"方案化疗,对照组单独使用TP方案化疗,持续观察2周期,每周期21天。治疗前和治疗两个周期后各评价1次,共评价2次。观察治疗组和对照组患者在治疗前后肿瘤大小、血清肿瘤标志物、KPS评分、中医证候、毒副反应等指标并运用统计学进行评价。结果:1.在瘤体大小评价方面,治疗组瘤体缓解有效率高于对照组,但两组间比较无统计学差异(P0.05)。2.治疗组和对照组在治疗前和治疗2周期后血清肿瘤标志物CEA、SCC浓度比较,治疗组优于对照组,P0.05,差异有统计学意义。3.在KPS评分方面,治疗组和对照组在治疗后均高于治疗前,有统计学差异(P0.05),且治疗组KPS评分较对照组升高更明显,有统计学差异(P0.05)。4.在中医证候积分方面,治疗组治疗后较治疗前下降,差异具有统计学意义(P0.05);对照组治疗前后比较无统计学差异(P0.05)。5.在毒副反应方面,治疗组和对照组相比,白细胞减少、恶心呕吐的发生率均明显减低,有统计学差异(P0.05)。结论:1.开郁化痰法具有稳定瘤体大小的作用。2.开郁化痰法联合TP方案可降低痰气交阻型中晚期食管癌患者的血清肿瘤标志物。3.开郁化痰法联合TP方案可缓解痰气交阻型中晚期食管癌患者的临床症状,提高患者KPS评分及生活质量。4.开郁化痰法可以降低化疗引起的骨髓抑制及恶心呕吐发生率。
[Abstract]:Objective: to observe the clinical effect of open depression and phlegm therapy combined with TP regimen in the treatment of middle and advanced esophageal carcinoma. Methods: 80 cases of middle and late stage esophageal squamous cell carcinoma with phlegm and qi obstruction were randomly divided into treatment group and control group. The treatment group was treated with open depression and phlegm therapy combined with "TP" regimen chemotherapy, while the control group was treated with TP regimen chemotherapy alone, and observed for 2 cycles for 21 days each. There were 2 evaluations before and after two cycles of treatment. The tumor size, serum tumor markers and KPS scores, TCM syndromes, toxic and side effects were observed and evaluated by statistics before and after treatment in the treatment group and the control group. The result is 1: 1. In the evaluation of tumor size, the effective rate of tumor remission in the treatment group was higher than that in the control group, but there was no statistical difference between the two groups. The concentration of serum tumor marker CEA SCC in the treatment group and the control group was higher than that in the control group before and after 2 cycles treatment, and the difference was statistically significant. The KPS score of the treatment group and the control group was higher than that of the control group after treatment, there was statistical difference (P 0.05), and the KPS score of the treatment group was significantly higher than that of the control group (P 0.05. 4). In TCM syndromes integral, the treatment group after treatment than before treatment decreased, the difference was statistically significant (P0.05A); the control group before and after treatment there was no statistical difference (P0.05U. 5). The incidence of leukopenia, nausea and vomiting in the treatment group was significantly lower than that in the control group (P 0.05). Conclusion 1. The method of opening depression and resolving phlegm has the effect of stabilizing the size of tumor. Kaiyu Huatan method combined with TP regimen can reduce the serum tumor marker of patients with middle and late stage esophageal carcinoma with phlegm and qi obstruction. The combination of open depression and resolving phlegm therapy combined with TP regimen can relieve the clinical symptoms of patients with middle and late stage esophageal cancer with phlegm and qi obstruction, and improve the KPS score and quality of life of patients. It can reduce the incidence of bone marrow depression and nausea and vomiting caused by chemotherapy.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

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