微RNA-146a基因rs2910164多态性与胃癌易感性的Meta分析

发布时间：2018-05-26 14:08

  本文选题：胃肿瘤 + 微RNAs　； 参考：《肿瘤》2014年08期

【摘要】：目的 :探讨微RNA-146a(microRNA-146a,miRNA-146a)基因rs2910164位点多态性与胃癌易感性的关系。方法 :计算机检索PubMed、EMBASE、Cochrane Library、相关期刊论文、中国生物医学文献数据库、维普数据库和万方数据库,收集关于miRNA-146a rs2910164多态性与胃癌罹患风险关系的病例-对照研究。根据文献纳入及排除标准筛选研究文献,提取数据并进行质量评价。采用STATA 12.1软件进行Meta分析,计算合并比值比(odds ratio,OR)及95%可信区间(coni dence interval,CI),并进行亚组分析、敏感性分析和发表偏倚检测。结果 :共纳入8个病例-对照研究,包括胃癌患者4 308例,非肿瘤对照者6 320例。Meta分析结果显示,miRNA-146a rs2910164多态性与胃癌罹患风险无统计学相关性(C vs G:OR=0.95,95%CI:0.84~1.08;GG+CG vs CC:OR=1.05,95%CI:0.85~1.29;GG vs CC+CG:OR=1.12,95%CI:0.94~1.34;CC vs GG:OR=0.91,95%CI:0.71~1.16;CG vs GG+CC:OR=0.95,95%CI:0.88~1.03)。敏感性分析时剔除了异质性较大的一篇研究(Okubo等)后,C vs G及CC vs GG模型基因多态性与胃癌易感性相关,差异有统计学意义(OR=0.87,95%CI:0.84~0.95;OR=0.80,95%CI:0.70~0.91)。根据Lauren’s分型的亚组分析显示,GG vs CC+CG模型基因多态性与肠型胃癌的罹患风险增高相关(OR=1.24,95%CI:1.04~1.48)。结论 :miRNA-146a基因rs2910164位点多态性可能与胃癌易感性无相关性。
[Abstract]:Objective: to investigate the relationship between the rs2910164 polymorphism of microRNA-146a simiRNA-146a) gene and the susceptibility to gastric cancer. Methods: a computer-based search of PubMedus EMBASE Cochrane Library, full text Database of Chinese Journals, Chinese Biomedical Literature Database, Weip Database and Wanfang Database was conducted to collect case-control studies on the relationship between miRNA-146a rs2910164 polymorphism and gastric cancer risk. According to the inclusion and exclusion criteria, the research documents were selected, the data were extracted and the quality was evaluated. STATA 12.1 software was used for Meta analysis. The odds ratio (OR) and 95% confidence interval (CI) were calculated. Subgroup analysis, sensitivity analysis and publication bias test were performed. 缁撴灉 :鍏辩撼鍏，

本文编号：1937507