高表达的Wnt分泌蛋白1促进肺癌化疗耐受

发布时间：2018-05-26 17:37

本文选题：Wnt分泌蛋白 + 肺癌　；参考：《中国老年学杂志》2017年24期

【摘要】：目的探讨Wnt分泌蛋白(WISP)1在肺癌中的表达量及作用。方法生物信息学分析WISP1在肺癌及癌旁组织中的表达量,qRTPCR检测肺癌组织及癌旁组织中WISP1 mRNA的表达。在肺癌细胞中干预WISP1的表达,检测处理后细胞化疗敏感性的变化。结果生物信息学分析免疫组化数据库联合qRT-PCR结果发现,WISP1 mRNA在肺癌中的表达量显著高于癌旁组织,且WISP1在肺癌化疗耐受组的表达量显著高于化疗敏感组。在肺癌细胞中敲低WISP1对化疗药物奥沙利铂的敏感性增加,反之亦然。结论 WISP1在肺癌中高表达且促进肺癌化疗耐受。
[Abstract]:Objective to investigate the expression and role of Wnt secretory protein (WISP) 1 in lung cancer. Methods the expression of WISP1 in lung cancer and paracancerous tissues was analyzed by bioinformatics. The expression of WISP1 mRNA in lung cancer and paracancerous tissues was detected by qRT PCR. The expression of WISP1 was interfered in lung cancer cells and the changes of chemosensitivity after treatment were detected. Results the expression of WISP1 mRNA in lung cancer was significantly higher than that in paracancerous tissues, and the expression of WISP1 in chemoresistance group was significantly higher than that in chemosensitive group. The sensitivity of WISP1 to oxaliplatin is increased in lung cancer cells and vice versa. Conclusion WISP1 is highly expressed in lung cancer and promotes chemotherapy tolerance in lung cancer.
【作者单位】：广州医科大学附属肿瘤医院;
【基金】：国家自然科学基金项目(81602016,81472184) 广州市卫计委一般引导项目(20171A011321) 广东省医学科学技术研究基金(A2017362)
【分类号】：R734.2

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