表观弥散系数平均值及最小值与肝癌病理学特征的相关性研究

发布时间：2018-05-28 10:58

本文选题：肝肿瘤 + 病理学　；参考：《中国临床医学影像杂志》2017年11期

【摘要】：目的:探讨表观弥散系数平均值(ADC_(mean))、最小值(ADC_(min))在鉴别肝癌病理分化程度的价值。方法:回顾性分析46例经病理证实的肝癌患者,包括肝细胞癌(36例)、胆管细胞癌(10例),并将其分为高、中、低分化组(分别为10、24、12例)。所有患者均行MRI平扫、增强及DWI序列扫描,综合各扫描序列,测量病灶实质部分的ADC_(mean)值、ADC_(min)值,对比ADC值在高、中、低分化肝癌中的差异。采用受试者工作特征曲线(ROC)分析ADC_(min)值在鉴别低分化与中高分化肝癌的临界值及其敏感度、特异度。结果:低分化组ADC_(mean)值及ADC_(min)值均低于中分化和高分化组,且差异具有统计学意义(P0.05);在低分化与中高分化肝癌的鉴别中,ADC_(min)值具有较高的诊断效能,ROC曲线下面积(AUC)为0.842,其敏感度、特异度分别为86.2%、71.4%。结论:ADC_(min)值在预测肝癌的病理分化程度中的作用要优于ADC_(mean)值。
[Abstract]:Objective: to investigate the value of the average apparent diffusion coefficient (ADCS) in differentiating the pathological differentiation of hepatocellular carcinoma (HCC). Methods: a total of 46 patients with liver cancer, including 36 patients with hepatocellular carcinoma and 10 patients with cholangiocarcinoma, were retrospectively analyzed. The patients were divided into high, middle and low differentiation groups (10: 24). All patients were examined with MRI plain scan, enhanced scan and DWI sequence. The mean value of ADCS in the solid part of the lesion was measured, and the difference of ADC value in high, middle and low differentiated liver cancer was compared. The critical value, sensitivity and specificity of ADCS / min value in differentiating poorly differentiated and moderately well differentiated liver cancer were analyzed by using the operating characteristic curve of subjects. Results: the mean value of ADCC and ADCC / min in low differentiation group were lower than those in medium differentiation group and high differentiation group, and the difference was statistically significant (P 0. 05), and the value of ADCD min in low differentiation and high differentiation liver cancer had higher diagnostic efficacy and area under ROC curve (AUC) was 0.842, its sensitivity was 0. 842, and the difference was significant (P < 0. 05). The specificity was 86.2 and 71.4, respectively. Conclusion the value of the weight of ADCS in predicting the degree of pathological differentiation of HCC is better than the mean value of ADCC.
【作者单位】：南京医科大学附属淮安第一医院影像科;
【分类号】：R445.2;R735.7

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