终末期乳腺癌患者高危型HPV感染与Stat3活性及IL-17表达意义研究

发布时间：2018-05-30 10:57

本文选题：乳腺癌 + 白细胞介素-　；参考：《中华医院感染学杂志》2017年23期

【摘要】：目的探讨终末期乳腺癌患者高危型人乳头瘤状病毒(HPV)感染与信号转导与转录活化因子(Stat3)活性及白细胞介素-17(IL-17)表达意义,为乳腺癌的治疗提供理论依据。方法随机选取2013年3月-2016年2月宁波市第二医院收治的156例乳腺癌患者石蜡组织标本,同时收集患者的肿瘤大小、年龄等临床病理资料,用免疫组化的方法检测了乳腺癌中的Stat3活性的表达和IL-17的表达。结果 156例乳腺癌中Stat3的活化状态即p-Stat3有强阳性(2+--3+)表达的127例;阳性(+)表达的为28例,表达阴性(-)的有1例,对156例乳腺癌中HPV与Stat3信号通路的活化进行双变量的相关性分析,Spearman相关系数(rs)为0.089,P=0.091,说明乳腺癌中HPV感染与的p-Stat3表达量不相关;156例有78例强阳性(2+--3+)表达,有59例阳性(+)表达,有19例IL-17表达为阴性(-)的;对156例乳腺癌中HPV感染与IL-17的表达进行双变量的相关性分析,Spearman相关系数(rs)为-0.169,P=0.001,说明乳腺癌中HPV感染与IL-17的表达量之间有相关性。结论 HPV感染与的p-Stat3表达量无相关性,HPV感染与IL-17的表达量之间有相关性,临床上可通过检测IL-17的表达量判断HPV感染。
[Abstract]:Objective to investigate the significance of high risk human papillomavirus (HPV) infection signal transduction and transcriptional activator (Stat3) activity and interleukin-17 (IL-17) expression in patients with end-stage breast cancer and to provide a theoretical basis for the treatment of breast cancer. Methods 156 paraffin tissue specimens from the second Hospital of Ningbo City from March 2013 to February 2016 were randomly selected, and the tumor size, age and other clinicopathological data were collected at the same time. The expression of Stat3 activity and IL-17 in breast cancer were detected by immunohistochemical method. Results among the 156 cases of breast cancer, there were 127 cases with strong positive expression of p-Stat3, 28 cases with positive expression and 1 case with negative expression of Stat3. Bivariate correlation analysis of activation of HPV and Stat3 signaling pathway in 156 cases of breast cancer. The correlation coefficient of Spearman correlation coefficient was 0.089 Stat3 0.091, which indicated that there were 78 cases with strong positive expression of p-Stat3 in 156 cases of breast cancer, which showed that there was no correlation between HPV infection and the expression of p-Stat3 in 156 cases. 59 cases were positive and 19 cases were negative for IL-17. The bivariate correlation analysis of HPV infection and IL-17 expression in 156 cases of breast cancer showed that there was a correlation between HPV infection and the expression of IL-17 in breast cancer. Conclusion there is no correlation between HPV infection and the expression of p-Stat3. There is no correlation between HPV infection and the expression of IL-17. HPV infection can be judged by detecting the expression of IL-17 in clinic.
【作者单位】：宁波市第二医院乳腺外科;绍兴市人民医院乳腺外科;
【基金】：浙江省医药卫生平台基金资助项目(2015DTA018)
【分类号】：R737.9

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