胃癌组织中LncRNA RP11-513G11.1的表达及其临床意义

发布时间：2018-06-01 11:22

本文选题：胃肿瘤 + 基因表达　；参考：《肿瘤》2017年02期

【摘要】：目的:探讨长链非编码RNA(long non-coding RNA,LncRNA)RP11-513G11.1在胃癌组织中的表达及其临床意义。方法 :应用实时荧光定量PCR法检测92例胃癌组织、70例癌旁组织及22例正常胃组织中LncRNA RP11-513G11.1的表达,分析LncRNA RP11-513G11.1表达与胃癌患者临床病理特征及预后的关系。结果 :胃癌组织中LncRNA RP11-513G11.1的表达水平显著高于癌旁组织及正常胃组织(P值均0.01)。LncRNA RP11-513G11.1表达与胃癌患者的TNM分期、淋巴结转移、远处转移、肿瘤分化及生存状态显著相关(P值均0.01)。LncRNA RP11-513G11.1高表达的胃癌患者的总生存时间及无进展生存时间均短于低表达患者(P值均0.01)。LncRNA RP11-513G11.1表达、远处转移及TNM分期是胃癌患者预后的独立影响因素(P值均0.01)。结论 :胃癌组织中LncRNA RP11-513G11.1高表达,并且LncRNA RP11-513G11.1的表达是胃癌患者预后的独立影响因素。
[Abstract]:Objective: to investigate the expression and clinical significance of LncRNA-LncRNA-RP11-513G11.1 in gastric carcinoma. Methods: the expression of LncRNA RP11-513G11.1 in 92 cases of gastric carcinoma and 22 cases of normal gastric tissues was detected by real-time fluorescence quantitative PCR. The relationship between the expression of LncRNA RP11-513G11.1 and the clinicopathological features and prognosis of gastric cancer was analyzed. Results: the expression of LncRNA RP11-513G11.1 in gastric cancer was significantly higher than that in paracancerous tissues and normal gastric tissues. The expression of 0.01).LncRNA RP11-513G11.1 was significantly higher than that of TNM staging, lymph node metastasis and distant metastasis in gastric cancer. There was a significant correlation between tumor differentiation and survival status. The total survival time and progression free survival time of gastric cancer patients with high expression of 0.01).LncRNA RP11-513G11.1 were shorter than those of patients with low expression. Distant metastasis and TNM stage were independent prognostic factors in patients with gastric cancer (P = 0.01). Conclusion: the high expression of LncRNA RP11-513G11.1 and the expression of LncRNA RP11-513G11.1 are independent prognostic factors in gastric cancer.
【作者单位】：四川省人民医院消化内科;四川大学华西医院消化内科;
【分类号】：R735.2

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