外泌小体在白血病细胞和骨髓间充质干细胞交叉对话中的作用

发布时间：2018-06-02 02:10

本文选题：白血病 + 骨髓间充质干细胞　；参考：《中国实验血液学杂志》2017年04期

【摘要】：越来越多的证据提示,骨髓微环境在白血病的发生、发展和耐药等过程中发挥着重要的作用,其不仅是造血干细胞增殖、分化和成熟的土壤,也是白血病微小残留病灶潜在的天然庇护所以及复发和产生多药耐药的根源。间充质干细胞(mesenchymal stem cells,MSC)是骨髓微环境中重要的基质细胞,在近年来被证明是影响白血病细胞生物学特性的主要因素之一。MSC和白血病细胞不仅可以通过直接接触相互影响,还可以通过分泌外泌小体(exosome)进行交叉对话。外泌小体由多种活细胞分泌的纳米级囊泡小体,其中含有蛋白质、RNA和mRNA等多种组分,参与细胞间的物质交换和信息交流,在多种生理和病理过程中发挥着重要作用。外泌体的研究是白血病与微环境的一个新兴领域,将极大地推动有关白血病的研究进展,为白血病治疗带来新的契机。
[Abstract]:More and more evidence suggests that bone marrow microenvironment plays an important role in the occurrence, development and drug resistance of leukemia. It is not only the soil where hematopoietic stem cells proliferate, differentiate and mature. It is also a potential natural shelter for minimal residual lesions of leukemia and a source of relapse and multi-drug resistance. Mesenchymal stem cells (MSCs) are important stromal cells in bone marrow microenvironment. In recent years, mesenchymal stem cells (MSCs) have been proved to be one of the main factors affecting the biological characteristics of leukemia cells. It can also be secreted by exosome-exosome) for cross-talk. A nanoscale vesicle body secreted by a variety of living cells, containing a variety of components, such as mRNA and protein, which participate in the intercellular material exchange and information exchange, and play an important role in many physiological and pathological processes. The study of exocrine is a new field of leukemia and microenvironment, which will greatly promote the research progress of leukemia and bring a new opportunity for the treatment of leukemia.
【作者单位】：南昌大学第二附属医院血液重点实验室;南昌大学研究生院医学部;
【分类号】：R733.7

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