影响软骨肉瘤术后复发的因素分析

发布时间：2018-06-02 23:52

  本文选题：软骨肉瘤 + 手术治疗　； 参考：《山西医科大学》2017年硕士论文

【摘要】：目的:软骨肉瘤是临床工作中一种比较常见的恶性骨肿瘤,目前普遍认为这种恶性肿瘤对放化疗等辅助治疗的敏感性比较差,因此其主要治疗手段为手术切除。本研究回顾分析了2004年6月至2014年6月在我院经X线、CT、MRI检查及病理检查诊断确诊为软骨肉瘤并接受手术的患者,一共34例,并探讨影响患者术后复发的因素。方法:分析了2004年6月至2014年6月在我院经辅助检查及病理诊断确诊为软骨肉瘤并接受手术的病例。假定影响术后复发的因素为:年龄、性别、瘤体的大小、发病部位、病程长短、肿瘤细胞的组织学分级、术前术后是否接受放化疗。术后按时、规律随访,了解病人术后局部的复发状况。用SPSS19.0软件对收集的数据进项单因素分析,计算每组的c2和P值。结果:于2004年6月至2014年6月在我院经X线、CT、MRI检查及病理学检查确诊为软骨肉瘤并接受了手术治疗的病人一共有34例,平均随访时间为4年。其中男性软骨肉瘤患者为20例,女性软骨肉瘤患者为14例,患者的患病年龄为17~78岁,平均患病年龄为46岁;病程为3~14月,平均7月;肿瘤大小5cm3~1500cm3,平均550cm3。肿瘤生长于四肢骨及肩胛骨的患者有19例,生长于中轴骨的患者有15例。肿瘤细胞的组织分级为Ⅰ级、Ⅱ级和Ⅲ级的患者分别为19例、10例和5例,接受放化疗的有6例,未接受放化疗的有28例。其中瘤体大小、肿瘤细胞组织学分级与术后的复发率有关(P0.05),患者的年龄、性别、发病部位、病程长短、术前术后是否接受放化疗与术后复发率在统计学上没有明显的相关性(P0.05)。结论:1.软骨肉瘤瘤体的大小、肿瘤细胞的组织病理学分级可以影响软骨肉瘤患者术后的复发率。2.年龄、性别、发病部位、病程长短、是否接受放化疗在软骨肉瘤患者术后复发率没有统计学差异。
[Abstract]:Objective: chondrosarcoma is a common malignant bone tumor in clinical work. From June 2004 to June 2014, 34 cases of chondrosarcoma diagnosed and operated by X-ray CT MRI and pathological examination in our hospital were retrospectively analyzed, and the factors influencing the recurrence of the patients were discussed. Methods: the cases of chondrosarcoma diagnosed and operated in our hospital from June 2004 to June 2014 were analyzed. It is assumed that the factors influencing recurrence after operation are age, sex, size of tumor, location of disease, duration of disease, histological grade of tumor cells, whether or not to receive radiotherapy and chemotherapy before and after operation. Follow up regularly and on time after operation to understand the local recurrence of patients. The data were analyzed by single factor analysis with SPSS19.0 software, and the values of C2 and P in each group were calculated. Results: from June 2004 to June 2014, 34 cases of chondrosarcoma were diagnosed and treated by CT MRI and pathology in our hospital. The average follow-up time was 4 years. There were 20 cases of male chondrosarcoma and 14 cases of female chondrosarcoma. The age of the disease was 1778 years old, the average age was 46 years, the course of disease was 3 ~ 14 months, the average was 7 months, and the tumor size was 5 cm ~ 3 ~ 1 500 cm ~ 3 with an average of 550 cm ~ 3. There were 19 cases of tumor growing in the limbs and scapula, and 15 cases of the axial bone. The tumor cells were classified as grade 鈪，

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