30例双原发肺癌的临床及预后因素分析

发布时间：2018-06-04 12:59

本文选题：肺肿瘤 + 多原发肺癌　；参考：《中国肺癌杂志》2017年10期

【摘要】：背景与目的多原发肺癌(multiple primary lung cancer,MPLC)是一种临床中较为少见的肺癌类型,双原发肺癌(double primary lung cancer,DPLC)是其中最常见的一种,近年来由于诊疗手段的进步检出率逐渐升高。本研究总结分析了30例DPLC患者的临床资料,以期为DPLC的诊疗提供理论依据。方法回顾郑州大学附属肿瘤医院2010年1月-2015年12月收治的30例DPLC患者的临床资料,对临床特征及预后相关因素进行分析。结果 30例中,同时性双原发癌(synchronous DPLC,s DPLC)占3例(3/30,10%),异时性双原发癌(metachronous DPLC,m DPLC)占27例(27/30,90.0%)。病灶好发于右肺上叶(20/60,33.3%),病理类型以腺癌(25/60,41.7%)为主,病理类型相同者(17/30,56.7%)多于不同者(13/30,43.3%),病理类型相同者以腺-腺(10/16,62.5%)最常见。生存分析显示淋巴结转移(HR=4.349,95%CI:1.435-13.178,P=0.009)和重度吸烟史(HR=2.996,95%CI:1.089-8.240,P=0.034)是DPLC的不良预后因素。结论 DPLC好发于右肺上叶,病理类型以腺癌为主,早期诊断、积极的治疗和严格的戒烟策略有望改善其预后。
[Abstract]:Background & objective multiple primary lung cancer with multiple primary lung cancer is a rare type of lung cancer in clinic. Double primary lung cancer is one of the most common types of lung cancer. In recent years, the detection rate of double primary lung cancer has gradually increased due to the progress of diagnosis and treatment. This study summarized and analyzed the clinical data of 30 patients with DPLC in order to provide theoretical basis for the diagnosis and treatment of DPLC. Methods the clinical data of 30 patients with DPLC admitted to the affiliated Cancer Hospital of Zhengzhou University from January 2010 to December 2015 were reviewed and the clinical characteristics and prognostic factors were analyzed. Results among the 30 cases, synchronous DPLCs (3 / 30) were found in 3 cases and metachronous DPLCm (DPLCc) in 27 cases (27 / 30). The pathological type was mainly adenocarcinoma 25 / 6041.7T (17 / 3030 / 56.7) more than 13 / 3033.3G, and the histopathologic type was 10 / 10- / 1662.5) (P < 0.05). The pathological type of the lesion was 25 / 6041.7T (P < 0.05). The pathological type of the lesion was more common than that of the patients with the same pathological type (25 / 6041.7T), and the histopathologic type was more common than that of the patients with the same pathological type. Survival analysis showed that HRI: 1.435-13.178P0.009) and heavy smoking history HR2.996C: 1.089-8.240P0.034) were the adverse prognostic factors of DPLC. Conclusion DPLC is more common in the upper lobe of the right lung with adenocarcinoma as the main pathological type, early diagnosis, active treatment and strict smoking cessation strategy, which is expected to improve its prognosis.
【作者单位】：郑州大学附属肿瘤医院呼吸内科;焦作市第二人民医院肿瘤内科一病区;
【分类号】：R734.2

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