光动力辅助内镜与白光成像辅助内镜治疗非浸润性膀胱癌疗效的Meta分析

发布时间：2018-06-05 03:22

本文选题：膀胱肿瘤 + 光动力诊断　；参考：《肿瘤》2017年04期

【摘要】：目的:系统评价光动力辅助内镜与白光成像辅助内镜治疗非浸润性膀胱癌的疗效。方法:检索1994年1月—2016年11月光动力辅助内镜治疗非浸润性膀胱癌的相关文献。检索的数据库包括Cochrance Libarary、PubMed、Embase、万方数据库、维普数据库和中国生物医学文献数据库。研究光动力和白光成像内镜治疗非浸润性膀胱癌后3个月、9个月、1年、2年和5年的复发率。在评价文献质量后,应用Review Manager 5.3软件进行Meta分析,结果以风险比及其95%可信区间予以表示。结果:共纳入10项临床随机对照试验,共2 430例患者。与白光成像辅助内镜治疗相比,光动力辅助内镜治疗非浸润性膀胱癌的9个月(风险比:0.80,95%可信区间:0.69~0.93;P=0.005)、1年(风险比:0.65,95%可信区间:0.46~0.91;P=0.010)、2年(风险比:0.54,95%可信区间:0.40~0.72;P0.001)和5年(风险比:0.76,95%可信区间:0.61~0.94;P=0.010)复发率显著较低。结论:与白光成像辅助内镜治疗非浸润性膀胱癌相比,光动力辅助内镜治疗术后5年内的复发率较低。
[Abstract]:Objective: to evaluate the efficacy of photodynamic assisted endoscopy and white light imaging assisted endoscopy in the treatment of non invasive bladder cancer. Methods: literature on the treatment of non invasive bladder cancer by moonlight assisted endoscopy from January 1994 to November 2016 was reviewed. The databases searched include Cochrance Libarary.PubMedbase, Wanfang database, Weip database and Chinese biomedical literature database. To study the recurrence rate of 3 months, 9 months, 1 year, 2 years and 5 years after photodynamic and white light imaging endoscopy for non-invasive bladder cancer. After evaluating the quality of literature, Meta analysis was carried out with Review Manager 5.3 software. The results were expressed as risk ratio and 95% confidence interval. Results: a total of 2 430 patients were enrolled in 10 randomized controlled trials. Compared with white light imaging assisted endoscopic therapy, Photodynamic assisted endoscopy was used to treat non-invasive bladder cancer for 9 months (0. 80% 95% confidence interval: 0. 69% CI: 0. 005, 1 year: 1: 0. 65% confidence interval: 0. 460. 91% confidence interval: 0. 460.91%, 2 years: 0. 5495% confidence interval: 0. 400. 722% P 0.001) and 5 years (risk ratio: 0. 766%: 0. 611% confidence interval: 0. 611 P0. 010). The recurrence rate was significantly lower than that for 1 year (0. 65% vs 0. 65% confidence interval: 0. 400. 72% P 0. 001) and 5 years (0. 76 95% confidence interval: 0. 611% P 0. 010). Conclusion: the recurrence rate of photodynamic assisted endoscopy is lower than that of white light assisted endoscopy in the treatment of non-invasive bladder cancer.
【作者单位】：兰州大学第二附属医院泌尿外科;
【分类号】：R737.14

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