核磁共振波谱检查在前列腺癌诊断及病情判断中的应用

发布时间：2018-06-09 06:14

本文选题：前列腺癌 + 核磁共振波谱　；参考：《山东医药》2017年48期

【摘要】：目的探讨核磁共振波谱检查在前列腺癌诊断及病情判断中的应用价值。方法选择前列腺癌患者32例作为观察组,前列腺增生患者30例作为对照组。两组均行常规MRI及核磁共振波谱检查,观察病灶波谱的曲线特征及枸橼酸盐、胆碱、肌酸的化学位移情况,计算CC/C。CC/C=(胆碱+肌酸)/枸椽酸盐。采用化学发光免疫法检测血清前列腺特异性抗原,根据MRI检查结果计算前列腺体积,并计算前列腺特异抗原密度(PSAD)。绘制CC/C与PSAD单独或联合检测诊断前列腺癌的受试者工作特征(ROC)曲线,比较其诊断效能;分析CC/C与Gleason评分的关系。结果观察组与对照组CC/C分别为1.38±0.30、0.85±0.18,PSAD分别为1.10±0.18、0.29±0.19,两组比较P均0.05。CC/C联合PSAD诊断前列腺癌的ROC曲线下面积、敏感性及特异性均高于CC/C与PSAD单独诊断。观察组CC/C与Gleason评分呈正相关(r=0.815,P0.01)。结论核磁共振波谱检查联合PSAD可提高对前列腺癌的诊断效能;有助于对患者的病情判断及预后评估。
[Abstract]:Objective to evaluate the value of nuclear magnetic resonance spectroscopy (NMR) in the diagnosis and diagnosis of prostate cancer. Methods 32 cases of prostate cancer and 30 cases of benign prostatic hyperplasia were selected as observation group and control group respectively. Both groups were examined by conventional MRI and nuclear magnetic resonance spectroscopy (MRI). The curve characteristics of focus spectrum and chemical shifts of citrate, choline and creatine were observed, and CCR / C / C (choline creatine / citrate) were calculated. The prostate specific antigen was detected by chemiluminescence immunoassay. The prostate volume was calculated by MRI and the density of prostate specific antigen (PSAD) was calculated. To compare the diagnostic efficacy of CC-C and PSAD, and to analyze the relationship between CC-C and Gleason score. Results the CCR / C of the observation group and the control group were 1.38 卤0.30 卤0.85 卤0.18 and 1.10 卤0.18 卤0.29 卤0.19, respectively. The area under the ROC curve, the sensitivity and specificity of the two groups were higher than those of the CC-C and PSAD alone. There was a positive correlation between CCR / C and Gleason score in the observation group. Conclusion Magnetic Resonance Spectroscopy combined with PSAD can improve the diagnostic efficiency of prostate cancer, and is helpful to judge the patient's condition and evaluate the prognosis.
【作者单位】：南京医科大学附属淮安第一医院;
【分类号】：R737.25

【相似文献】