胸腺基质淋巴细胞生成素与肿瘤发生发展的关系

发布时间：2018-06-10 10:45

本文选题：胸腺基质淋巴细胞生成素 + 恶性肿瘤　；参考：《中国肿瘤生物治疗杂志》2017年01期

【摘要】：胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)是一种主要由皮肤、肺、胸腺与胃肠道等器官的上皮细胞分泌的与IL-7类似的炎性细胞因子。TSLP是一种多功能的细胞因子,可以作用于多种细胞如T细胞、B细胞、DC和肿瘤细胞等,具有重要的生物学功能。近年来,越来越多的研究表明,TSLP能够调控肿瘤的发生发展。一方面,TSLP在结肠癌、皮肤癌以及初期乳腺癌、胰腺癌的发展阶段发挥了重要的抗肿瘤作用;另一方面,TSLP在胃癌、肺癌、子宫颈癌和急性淋巴细胞白血病等恶性肿瘤的发生发展过程中发挥促进肿瘤进展的作用,提示TSLP可作为相关肿瘤治疗的潜在靶点。本文综述了近年来TSLP及其信号通路,以及其与乳腺癌、胰腺癌、子宫颈癌、胃癌、结肠癌、肺癌、皮肤癌、B细胞急性淋巴细胞白血病等多种恶性肿瘤发生发展的关系的研究进展,旨在为相关肿瘤的诊断和治疗提供新的思路。
[Abstract]:Thymic stromal lymphopoietin (TSLP) is a kind of inflammatory cytokine similar to IL-7 secreted by epithelial cells of skin, lung, thymus and gastrointestinal tract. TSLP is a multifunctional cytokine. It can act on a variety of cells, such as T cell B cells, DC and tumor cells, and has important biological functions. In recent years, more and more studies have shown that TSLP can regulate tumor development. On the one hand, TSLP plays an important role in the development of colon cancer, skin cancer, primary breast cancer and pancreatic cancer; on the other hand, TSLP plays an important role in gastric cancer and lung cancer. TSLP plays an important role in the development of malignant tumors such as cervical cancer and acute lymphoblastic leukemia, suggesting that TSLP may be a potential target for tumor therapy. In this review, TSLP and its signal pathway, and their association with breast cancer, pancreatic cancer, cervical cancer, gastric cancer, colon cancer, lung cancer, were reviewed. In order to provide new ideas for the diagnosis and treatment of skin cancer B cell acute lymphoblastic leukemia and other malignant tumors.
【作者单位】：浙江大学医学院免疫学研究所;
【基金】：国家自然科学基金资助项目(No.31670877)~~
【分类号】：R730.2

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