癌症患者生命质量测定量表体系之头颈癌量表QLICP-HN（V2.0T）的研制与评价

发布时间：2018-06-10 13:30

本文选题：生命质量 + 头颈癌　；参考：《昆明医科大学》2017年硕士论文

【摘要】：[目的]研制癌症患者生命质量测定量表体系之头颈癌量表(The Quality of Life Instrument for Head and neck cancer,QLICP-HN)(V2.0T)以及欧洲癌症研究和治疗组织的EORTC生命质量测定量表QLQ-C30QLQ-HN35中文版量表,分别考评并比较两个量表。[方法]依据共性模块与特异模块相结合的研究思想,通过大量回顾国内外相关文献资料,结合国内外文化特点,以开发量表的程序化决策方式研制QLICP-HN量表,主要包括:访谈、小组集中讨论、统计分析结合临床实际等。同时通过量表汉化的一系列包括翻译、回译、文化调试等步骤研制QLQ-HN35中文版,再同已有的QLQ-C30中文版结合形成QLQ-C30QLQ-HN35中文版量表。采用两个量表在入院时对100例头颈癌患者进行第一次测试,并在患者入院2～3天进行第二次量表测试;在患者出院时进行第三次量表测试,通过最终的调查数据来考评两个量表的测量学特性(信度、效度、反应度),同时对两个量表进行比较。在处理数据分析时采用的统计学方法有:统计描述、配对t检验、相关性分析、探索性因子分析等。[结果]1.研制出了含16个条目的头颈癌特异模块,与已有含39个条目的共性模块QLICP-GM结合形成头颈癌患者生命质量量表QLICP-HN;同时,还研制出了 EORTCQLQ-C30QLQ-HN35 中文版量表。2.对QLICP-HN量表进行考评,结果显示该量表的重测信度为0.990,克朗巴赫系数为0.646,分半信度为0.673。相关分析和因子分析显示QLICP-HN量表的结构效度尚可,采用QLQ-C30QLQ-HN35中文版量表作为效标分析可知,r=0.756(P0.001),所以头颈癌患者生命质量测定量表与效标测定量表有较高的相关性,可以认为具有较好的效标效度。3.对QLQ-C30QLQ-HN35中文版量表进行考评,并将QLICP-HN量表与QLQ-C30QLQ-HN35中文版量表进行比较:从内容上看,两量表均能反映生命质量测量的基本内容,但存在异同点;从测量学特性上看,两量表的效度、反应度均较好,信度尚可,其中结构效度、反应度接近,且均具有较好的内容效度。[结论]头颈癌患者生命质量量表QLICP-HN有良好的效度、反应度,信度尚可,可用于中国头颈癌患者生命质量的测评。QLICP-HN量表与QLQ-C30QLQ-HN35中文版量表比较,内容上存在异同点;测量学特征上两量表类似。
[Abstract]:[objective] to develop the quality of Life instrument for head and neck Cancer scale (QLLICP-HNU V2.0T) and the quality of Life scale (QLQ-C30QLQQ-H35) of European Organization for Research and treatment of Cancer. The two scales were evaluated and compared. [methods] the QLICP-HN scale was developed according to the research idea of combining the common module with the specific module, by reviewing a large number of domestic and foreign literature, combining with the characteristics of domestic and foreign culture, and developing the QLICP-HN scale by the way of programmed decision making of developing the scale, which mainly included: interview, etc. Group discussion, statistical analysis combined with clinical practice and so on. At the same time, the Chinese version of QLQ-HN35 was developed through a series of Chinese version of the scale, including translation, back translation and cultural debugging, and the QLQ-C30QLQ-HN35 Chinese version was formed by combining with the existing QLQ-C30 Chinese version. 100 patients with head and neck cancer were tested for the first time at admission with two scales, and the second scale was tested on the 2nd day after admission, and the third time when the patient was discharged from hospital. The measurement characteristics (reliability, validity, response) of the two scales were evaluated by the final survey data, and the two scales were compared. The statistical methods used in data analysis are: statistical description, paired t test, correlation analysis, exploratory factor analysis and so on. [result] 1. A specific model of head and neck cancer with 16 items was developed, which combined with the common module QLICP-GM with 39 items to form QLICP-HN.The EORTCQLQ-C30QLQ-HN35 Chinese version of QLICP-HN35 was also developed. The QLICP-HN scale was evaluated. The results showed that the test-retest reliability of QLICP-HN was 0.990, the Cronbach coefficient was 0.646, and the split-half reliability was 0.673. Correlation analysis and factor analysis showed that the structure validity of QLICP-HN scale was fairly good. The QLQ-C30QLQ-HN35 Chinese version scale was used to analyze the validity of QLICP-HN scale. The QLQ-C30QLQ-HN35 scale was used to analyze the validity of QLICP-HN scale. Therefore, there was a high correlation between QLICP-HN scale and QLQ-C30QQ-HN35 scale. It can be considered that it has good standard validity. 3. The Chinese version of QLQ-C30QLQ-HN35 was evaluated, and the QLICP-HN scale was compared with QLQ-C30QLQQ-HN35. Among them, the structure validity and the reaction degree were close, and all had good content validity. [conclusion] QLICP-HN has good validity, response and reliability. It can be used to evaluate QLICP-HN and QLQ-C30QLQQ-HN35 in China. There are some similarities and differences between QLICP-HN and QLQ-C30QLQ-HN35. The characteristics of the two scales are similar.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.91

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