4E-BP1及其磷酸化形式在子宫内膜样腺癌中的表达及意义

发布时间：2018-06-13 18:28

本文选题：子宫内膜癌 + 4E-BP1　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:研究不同子宫内膜组织中真核细胞翻译起始因子4E结合蛋白1(eukaryotic initiation factor 4E-binding protein 1,4E-BP1)、磷酸化4E-BP1(phosphorylated 4E-BP1,p-4E-BP1)的表达,探讨其与子宫内膜癌的临床病理特征及预后的关系。方法:采用免疫组化法分别检测子宫内膜样腺癌、子宫内膜非典型增生及正常子宫内膜组织中4E-BP1、p-4E-BP1的表达情况,并结合患者的年龄、肿瘤的组织病理学分级、手术病理分期、淋巴结转移、肌层浸润、腹水细胞学等临床病理特征进行分析。结果:(1)4E-BP1在正常子宫内膜组织、非典型增生内膜、子宫内膜样腺癌组织中的阳性表达率分别为81.8%(18/22)、33.3%(9/27)、20.9%(13/62),差异具有统计学意义(P0.05)。p-4E-BP1在三者之间的阳性率逐渐升高,分别为22.7%(5/22)、59.3%(16/27)、82.3%(51/62),组间差异具有统计学意义(P0.05)。(2)4E-BP1的表达与子宫内膜样腺癌的临床病理特征之间无明显相关性(P0.05)。(3)p-4E-BP1的表达与子宫内膜癌的组织学分级、肌层浸润有关(P均0.05),随着组织学分化程度的降低,p-4E-BP1的表达增加(p0.05),在深肌层浸润的子宫内膜样腺癌中,P-4E-BP1的表达较浅肌层浸润癌显著增加(P0.05)。P-4E-BP1的表达与年龄、手术病理分期、淋巴结转移及腹水细胞学之间无明显相关性(P0.05)。结论:1.4E-BP1的表达与子宫内膜样腺癌的临床病理特征之间并无关联(P0.05);2.p-4E-BP1的表达与子宫内膜样腺癌的组织学分级、肌层浸润有关,可能可以作为预后指标。
[Abstract]:Objective: to study the expression of eukaryotic translation initiation factor 4E binding protein 1(eukaryotic initiation factor 4E-binding protein 1, phosphorylated 4E-BP1P 1 and phosphorylated 4E-BP1P 1 in different endometrial tissues, and to explore the relationship between the expression of 4E-binding protein 4E-binding protein 1and the clinicopathological features and prognosis of endometrial carcinoma. Methods: immunohistochemical method was used to detect the expression of 4E-BP1p-4E-BP1 in endometrioid adenocarcinoma, endometrial atypical hyperplasia and normal endometrium. The clinicopathological features of lymph node metastasis, myometrial infiltration and ascites cytology were analyzed. Results the positive expression rates of 4E-BP1 in normal endometrial tissue, atypical hyperplasia endometrium and endometrial adenocarcinoma were 81.8 / 1822 / 33. 3% respectively. The positive rate of P 0.05. P-4E-BP1 increased gradually between the three groups. There was no significant correlation between the expression of P0.05 and the clinicopathological features of endometrial adenocarcinoma and the expression of P0.05. 3p-4E-BP1 and histological grade of endometrial carcinoma. The expression of p-4E-BP1 increased with the decrease of histological differentiation. The expression of P-4E-BP1 was significantly increased in endometrial adenocarcinoma with deep myometrium invasion than that in superficial myometrial infiltrating carcinoma. The expression of P-4E-BP1 was significantly increased in patients with deep myometrial invasion than in superficial myometrial infiltrating carcinoma, and the expression of P-4E-BP1 was significantly higher than that of superficial myometrial infiltrating carcinoma, and the expression of P-4E-BP1 was significantly higher than that of superficial myometrial infiltrating carcinoma. There was no significant correlation between lymph node metastasis and ascites cytology. Conclusion there is no correlation between the expression of 1: 1.4E-BP1 and the clinicopathological features of endometrial adenocarcinoma. The expression of P0.05E-BP1 is related to the histological grade and myometrium infiltration of endometrial adenocarcinoma. It may be used as a prognostic index.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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