非小细胞肺癌血清中lncRNA HOTAIR的表达及临床意义

发布时间：2018-06-15 03:09

本文选题：肺肿瘤 + 长链非编码RNA　；参考：《中国肺癌杂志》2017年06期

【摘要】：背景与目的长链非编码RNA HOX转录反义RNA(HOX transcript antisense RNA,HOTAIR)在多种肿瘤中异常表达。本研究旨在探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)患者血清中lnc RNA HOTAIR的水平及其临床意义。方法采用实时定量聚合酶链反应(polymerase chain reaction,PCR)方法检测64例NSCLC患者和64例正常对照血清中HOTAIR的水平,统计分析血清中HOTAIR的水平与NSCLC临床病理参数之间的关系。结果与正常对照组相比,NSCLC患者血清中HOTAIR水平明显升高,两组之间的差异具有统计学意义(P0.01)。血清中HOTAIR水平与NSCLC患者的肿瘤大小、(tumor-node-metastasis,TNM)分期及淋巴转移有关(P0.05),而与患者的年龄、性别、吸烟、分化程度及病理类型均无明显相关(P0.05)。结论 NSCLC患者血清中HOTAIR水平明显升高,HOTAIR可能参与了NSCLC的发病过程。
[Abstract]:Background & objective: long chain noncoding RNAHOX transcriptional antisense RNAs HOX transcript antisense RNAs (HOTAIRs) are expressed abnormally in various tumors. The aim of this study was to investigate the level and clinical significance of lnc RNA HOTAIR in serum of patients with non small cell lung cancer (NSCLC). Methods the levels of HOTAIR in 64 patients with NSCLC and 64 normal controls were detected by real-time quantitative polymerase chain reaction- PCR. The relationship between the level of HOTAIR and the clinicopathologic parameters of NSCLC was statistically analyzed. Results compared with the normal control group, the serum HOTAIR level of NSCLC patients was significantly higher than that of the control group, and the difference between the two groups was statistically significant (P 0.01). The level of HOTAIR in serum was related to tumor size, lymph node metastasis and tumor size of NSCLC patients (P 0.05), but had no significant correlation with age, sex, smoking, differentiation and pathological type of NSCLC. Conclusion the serum HOTAIR level in patients with NSCLC may be involved in the pathogenesis of NSCLC.
【作者单位】：西安市第一医院干部病房科;
【分类号】：R734.2

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