MicroRNA21表达与乳腺癌临床病理特征相关性的Meta分析

发布时间：2018-06-18 08:54

  本文选题：microRNA21 + 乳腺癌　； 参考：《山西医科大学》2017年硕士论文

【摘要】：目的:采用Meta分析系统评价乳腺癌患者中microRNA21的高表达与其临床病理特征之间的相关关系,为人们对乳腺癌的临床诊疗思维带来新的启迪与深化。方法:使用互联网检索英文数据库pubmed、medline、embase以及中文数据库中国知网、万方数据库、维普数据库等相关数据库,根据一定的检索方法,网罗国外和国内公开发表的所有关于乳腺癌中microRNA21的高表达与乳腺癌发病特征及临床病理资料的相关性的文献,对契合既定的纳入标准的文献筛选,然后对其中所要用到的相关数据进行统计归纳。检索年限分别从相关数据库创建开始,结束时间是2016年10月31日。应用Review Manager5.3软件进行Meta分析,提取的数据采用比值比(odds ratio,OR),OR的95%可信区间(confidence interval,CI)来表示,根据计算结果绘制相关指标的森林图,通过漏斗图进行发表偏倚的评价,并对文献进行敏感性分析,采用合适的效应模型对数据进行统计分析,以P=0.05为检验水准,如果P0.05可视为差异有统计学意义。结果:本次荟萃分析共纳入10篇参考文献,有1270名符合标准的乳腺癌患者。Meta分析结果:月经状态(是否绝经):OR=1.66,95%CI为0.93-2.93,P=0.08;肿瘤直径大小(2cm):(OR=1.57,95%CI为0.81-3.02,P=0.18);组织学分级(II、III级与I级):OR=3.59,95%CI为1.92-6.74,P0.0001,(III级与I、II级):OR=2.08,95%CI为1.15-3.76,P=0.01;淋巴结的转移:OR=2.45,95%CI为1.92-3.13,P0.0001;肿瘤TNM分期:OR=2.46,95%CI为1.67-3.62,P0.0001;人类表皮生长因子受体2(Her-2):OR=1.95,95%CI为1.47-2.58,P0.0001;ER:OR=0.99,95%CI0.56-2.90P=0.08;PR:OR=1.12,95%CI0.54-2.32,P=0.75。结论:1.乳腺癌患者中,microRNA21的高表达与肿瘤的较高的组织学分级、淋巴结阳性转移、临床高TNM分期、Her2阳性表达有相关性,与月经状态、肿瘤大小、ER阳性表达、PR阳性表达无相关性。2.miR-21的表达情况可作为乳腺癌筛查及术前检查的一种标记物,在对乳腺癌预后判断以及制定合理的个体化治疗方面具有很大的潜力。
[Abstract]:Objective: to evaluate the correlation between the high expression of microRNA21 and its clinicopathological features in breast cancer patients by Meta-analysis system, and to bring new enlightenment and deepening to the clinical diagnosis and treatment thinking of breast cancer. Methods: the English database pubmedmedlineembase and the Chinese databases, such as China Zhiwang, Wanfang and Weipu databases, were searched on the Internet. To include all published foreign and domestic literature on the correlation between the high expression of microRNA21 in breast cancer and the characteristics and clinicopathological data of breast cancer, and to screen the literature that conforms to the established inclusion criteria, Then the relevant data to be used in statistical induction. The retrieval period starts with the creation of the related database and ends on October 31, 2016. Meta-analysis was carried out with the software Review Manager 5.3. The extracted data were expressed by 95% confidence intervalor of odds ratio. Forest maps of relevant indicators were drawn according to the calculated results, and publication bias was evaluated by funnel maps. And the sensitivity of the literature analysis, using the appropriate effect model for statistical analysis of the data, with P0. 05 as the test level, if P0.05 can be regarded as the difference has statistical significance. Results: a total of 10 references were included in this meta-analysis. 鏈，

本文编号：2034908