CCND1基因多态性与肝细胞癌遗传易感性的病例对照研究

发布时间：2018-06-19 03:14

本文选题：肝细胞癌(HCC) + 细胞周期蛋白(CCND)　；参考：《现代预防医学》2017年03期

【摘要】：目的探讨细胞周期蛋白D1基因(CCND1)rs9344位点多态性与肝细胞癌易感性的关联;方法采用病例对照研究,对经肝内穿刺活检确认的266例原发性肝细胞癌新发病例及经年龄、性别匹配的306例健康对照,应用MALDI-TOF法检测CCND1 rs9344基因多态性,以χ2检验比较CCND1基因型及相关危险因素在病例对照间分布的差异,采用非条件Logistic回归分析基因型与肝癌发病风险的关系。结果 CCND1 rs9344位点存在GG、GA、AA三种基因型,G/A等位基因及各基因型在肝癌组与对照组中分布未见明显差异,但在分层分析中发现,有肝脏疾病史人群中病例组AA基因型携带比例高于对照组,差异有统计学意义,与GG基因型相比,AA基因型伴有肝病史个体罹患肝细胞癌的风险比值比为5.29(OR=5.29,95%CI:1.42-24.49);结论 CCND1 rs9344位点多态性与肝细胞癌易感性无明显相关,AA基因型携带者且有肝脏疾病史对比其他基因型携带者患肝细胞癌的风险较高。
[Abstract]:Objective to investigate the association between CCND1rs9344 polymorphism of cyclin D1 gene and susceptibility to hepatocellular carcinoma (HCC). The polymorphism of CCND1 rs9344 gene was detected by MALDI-TOF method in 306 healthy controls matched by sex. The distribution of CCND1 genotype and related risk factors among the controls was compared by 蠂 2 test. Non-conditional logistic regression analysis was used to analyze the relationship between genotypes and the risk of liver cancer. Results there were no significant differences in the distribution of G / A alleles and genotypes between HCC group and control group, but there was no significant difference in the distribution of G / A alleles among the three genotypes in CCND1 rs9344 locus, but they were found in stratified analysis. The percentage of AA genotypes carried in the patients with history of liver disease was higher than that in the control group, and the difference was statistically significant. Compared with GG genotype, the ratio of CCND1 / AA genotype with liver disease history was 5.29 / 95 CI: 1.42-24.490.Conclusion there is no significant correlation between CCND1 rs9344 polymorphism and susceptibility to hepatocellular carcinoma (HCC) carriers and has a history of liver disease. There is a higher risk of hepatocellular carcinoma than other genotype carriers.
【作者单位】：厦门大学公共卫生学院;厦门市疾病预防控制中心;
【基金】：厦门市科技局社会发展项目3502Z20124023
【分类号】：R735.7

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