肠道菌群干预肿瘤负性免疫调控机制的研究进展

发布时间：2018-06-19 10:49

本文选题：肠道菌群 + 肿瘤　；参考：《中国肿瘤生物治疗杂志》2017年03期

【摘要】：肠道菌群不仅在人体的营养代谢、免疫稳态中扮演重要角色,还与恶性肿瘤进展密切相关。近年来,肠道菌群参与肿瘤免疫调控备受研究者关注,肠道菌群通过干预负性免疫调控网络影响肿瘤发生发展。然而,目前针对肠道菌群与肿瘤免疫调控关系的研究多停留于关联性分析,其分子作用机制尚未完全阐明。本文从肠道菌群干预肿瘤负性免疫调节细胞、负性免疫调节分子及负性免疫调节细胞因子等方面阐述肠道菌群干预肿瘤恶性进程的机制,以期为肿瘤治疗提供新的思路和策略。
[Abstract]:Intestinal flora not only plays an important role in human nutrition metabolism and immune homeostasis, but also is closely related to the progress of malignant tumor. In recent years, the intestinal microflora involved in tumor immune regulation has been concerned by researchers. Intestinal microflora affects tumor development through the intervention of negative immune regulatory network. However, the current studies on the relationship between intestinal flora and tumor immune regulation are mostly focused on the correlation analysis, and its molecular mechanism has not been fully elucidated. In this paper, the mechanism of intestinal microflora interfering with tumor negative immunomodulatory cells, negative immunomodulator molecules and negative immunomodulatory cytokines was discussed in order to provide new ideas and strategies for tumor treatment.
【作者单位】：昆明医科大学第三附属医院肿瘤生物治疗中心;
【基金】：国家自然科学基金资助项目(No.U1502222,No.81470005,No.81260307) 云南省科技厅应用基础研究项目资助(No.2015FB074,No.2014FB065,No.2014FB064) 云南省教育厅科学研究基金研究生项目资助(No.2016YJS057)~~
【分类号】：R730.3

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