EVI1基因在儿童急性髓细胞白血病中的表达及意义

发布时间：2018-06-20 14:34

本文选题：急性髓细胞白血病 + EVI基因　；参考：《临床儿科杂志》2017年05期

【摘要】：目的探讨EVI1基因表达与儿童急性髓细胞白血病(AML)临床表现及预后的关系。方法检测AML患儿EVI1基因表达,分析EVI1阳性AML患儿临床和实验室检查特点以及预后。结果 145例AML患儿中EVI1阳性38例,占26.21%。与阴性组相比,阳性组患儿的年龄、性别、血红蛋白量、白细胞及血小板计数、细胞形态学FAB分型、异常核型检出率差异均无统计学意义(P0.05);阴性组复杂核型检出率高于阳性组,差异有统计学意义(χ2=5.50,P=0.019)。38例阳性患儿中,14例化疗与7例异基因造血干细胞移植(allo-HSCT)患儿的无事件生存(EFS)率差异有统计学意义(χ2=4.00,P=0.045)。阳性组与阴性组患儿化疗完全缓解率差异无统计学意义(91.67%对91.18%,P0.05),阳性组患儿复发率高于阴性组,差异有统计学意义(64.29%对22.22%,P=0.009);两组EFS率差异也有统计学意义(χ2=5.76,P=0.015)。2例阳性组患儿骨髓复发时EVI1基因仍阴性。结论 EVI1基因是儿童AML的不良预后因素,allo-HSCT可改善EVI1阳性AML患儿预后。定量检测EVI1基因表达可能不适用于微小残留病监测。
[Abstract]:Objective to investigate the relationship between EVI1 gene expression and clinical manifestation and prognosis of childhood acute myeloid leukemia (AML). Methods the expression of EVI1 gene was detected in AML children. The clinical and laboratory features and prognosis of AML patients with EVI1 positive AML were analyzed. Results among 145 AML children, 38 cases were EVI 1 positive, accounting for 26.21%. There was no significant difference in age, sex, hemoglobin content, white blood cell and platelet count, cell morphological FAB typing, abnormal karyotype detection rate between the positive group and the negative group (P 0.05), but the detection rate of complex karyotype in the negative group was higher than that in the positive group. The difference was statistically significant (蠂 ~ 2 / 5.50 / P ~ (0.019) P ~ (0.019) among 38 positive children (14 / 38) and 7 (n = 7) allo-HSCT patients with allo-HSCT. There was a significant difference in EFSs (蠂 ~ (2 +) 4.00 / P ~ (0.045) in children with hematopoietic stem cell transplantation (HSCT). There was no significant difference in the complete remission rate of chemotherapy between the positive group and the negative group (91.67% vs 91.18%, P 0.05). The recurrence rate of the positive group was higher than that of the negative group. The difference was statistically significant (64.29% vs 22.22%, P < 0.009), and the difference of EFS rate between the two groups was also statistically significant (蠂 2 + 5.76%, P < 0.015.2). The EVI1 gene was still negative in the patients with bone marrow recurrence in the positive group. Conclusion EVI1 gene is a poor prognostic factor in childhood AML. Allo-HSCT can improve the prognosis of children with EVI1 positive AML. Quantitative detection of EVI 1 gene expression may not be suitable for minimal residual disease monitoring.
【作者单位】：重庆医科大学附属儿童医院儿童医院儿科研究所儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室;
【基金】：重庆市卫生计生委医学科研项目(No.2015msxm042)
【分类号】：R733.71

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