原发性食管小细胞癌患者的临床特征及预后

发布时间：2018-06-22 03:43

本文选题：食管癌 + 小细胞癌　；参考：《中国老年学杂志》2017年04期

【摘要】：目的探讨原发性食管小细胞癌患者的临床特征及预后。方法回顾性分析经病理证实行放射治疗的8例原发性食管小细胞癌患者的临床资料、治疗及生存情况。结果 8例食管小细胞癌患者占同期收治食管癌患者总数的2.0%。男/女为7/1,年龄56~71岁,病变均位于胸中和下段;首诊时5例为局限期。病变长度4~12(平均6)cm。放疗治疗的有效率为87.5%。1、2和3年生存率和无进展生存分别为50%、25%及12.5%和37.5%、12.5%及12.5%。局限期和广泛期中位生存时间(MST)分别为10个月(4~10个月)和22个月(14~41个月),两组差异显著(P=0.014)。结论原发性食管小细胞癌男性多见,病变多位于食管的中下段,放射治疗是局部治疗的有效方法,分期是影响预后的主要因素,全身化疗是推荐的重要治疗手段。
[Abstract]:Objective to investigate the clinical features and prognosis of primary small cell carcinoma of esophagus. Methods the clinical data, treatment and survival of 8 patients with primary esophageal small cell carcinoma treated with radiotherapy were retrospectively analyzed. Results eight patients with small cell carcinoma of the esophagus accounted for 2.0% of the total number of patients with esophageal cancer admitted in the same period. Male / female was 7 / 1, age 56 to 71 years old, the lesions were located in the middle and lower thoracic segment, and 5 cases were limited at the first visit. The length of lesion was 4 ~ 12 (mean 6) cm. The effective rates of radiotherapy were 87.5% and 12.5%, 12.5% and 12.5%, respectively. MST was 10 months (4 ~ 10 months) and 22 months (14 ~ 41 months) respectively, and the difference between the two groups was significant (P0. 014). Conclusion Primary small cell carcinoma of esophagus is more common in men, and the lesion is located in the middle and lower part of esophagus. Radiotherapy is an effective method for local treatment, staging is the main factor affecting prognosis, systemic chemotherapy is an important method of recommended treatment.
【作者单位】：兰州大学第一医院放疗科;中国医科大学附属第四医院放疗科;
【基金】：辽宁省临床能力建设项目(LNCC-B08-2014)
【分类号】：R735.1

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