广西地区原发性肝癌患者血清微囊藻毒素-LR水平研究

发布时间：2018-06-23 21:49

本文选题：肝肿瘤 + 微囊藻毒素类　；参考：《中国全科医学》2017年11期

【摘要】：目的探讨广西地区原发性肝癌患者血清微囊藻毒素-LR(MC-LR)的水平及其相关影响因素。方法选取2014年12月—2016年6月广西医科大学附属肿瘤医院收治的来自广西地区的144例原发性肝癌患者作为肝癌组,另选取同期本院体检健康者158例作为对照组。调查两组一般人口学特征、日常生活方式、饮食习惯等,并采集静脉血,采用酶联免疫吸附法(ELISA)检测血清乙型肝炎病毒(HBV)感染标志物,包括乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗体(HBsAb)、乙型肝炎核心抗体(HBcAb)、乙型肝炎e抗原(HBeAg)、乙型肝炎e抗体(HBeAb),以及MC-LR水平和谷胱甘肽(GSH)含量。结果肝癌组血清MC-LR水平为(0.078±0.039)μg/L,高于对照组的(0.061±0.041)μg/L(t=3.351,P0.01)。肝癌组和对照组中不同性别、年龄、民族、HBsAg阳性、吸烟、饮酒情况者血清MC-LR水平比较,差异均无统计学意义(P0.05);对照组中不同HBV感染者血清MC-LR水平比较,差异无统计学意义(P0.05);肝癌组和对照组中不同食鱼生、沟塘水饮用史者血清MC-LR水平比较,差异均有统计学意义(P0.05)。肝癌组GSH含量为(9.1±5.1)μg/L,低于对照组的(15.2±8.1)μg/L(t=-6.899,P0.001)。按照对照组血清MC-LR的中位数(0.042μg/L)进行暴露程度分层,肝癌组低暴露和高暴露人群GSH含量比较,差异无统计学意义(t=-1.290,P=0.200);对照组低暴露人群GSH含量高于高暴露人群(t=2.090,P=0.038)。结论广西地区原发性肝癌患者血清MC-LR水平高于健康人群,GSH含量低于健康人群。MC-LR高暴露的健康人群血清GSH含量低于MC-LR低暴露人群。食用鱼生、长期饮用沟塘水可升高血清MC-LR水平。
[Abstract]:Objective to investigate the level of serum microcystin -LR (MC-LR) and its related factors in the patients with primary liver cancer in Guangxi, and to select 144 cases of primary liver cancer from the Affiliated Cancer Hospital of Guangxi Medical University from December 2014 to June 2016 as the liver cancer group, and to select 158 healthy persons in the same period of the hospital. As a control group, the two groups of general demographic characteristics, daily lifestyle, dietary habits, and venous blood were collected, and enzyme linked immunosorbent assay (ELISA) was used to detect the serum hepatitis B virus (HBV) infection markers, including hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B core antibody (HBcAb), and B Hepatitis e antigen (HBeAg), hepatitis B e antibody (HBeAb), and MC-LR level and glutathione (GSH) content. The serum MC-LR level of liver cancer group was (0.078 + 0.039) mu g/L, higher than that of the control group (0.061 + 0.041) mu g/L (t=3.351, P0.01). The serum levels of different sex, age, nationality, HBsAg positive, smoking and drinking alcohol in the liver cancer group and the control group were in the liver cancer group and the control group. The difference was not statistically significant (P0.05), and there was no significant difference in serum MC-LR level in the control group (P0.05), and the difference in serum MC-LR level between the liver cancer group and the control group was statistically significant (P0.05). The GSH content of the liver cancer group was (9.1 + 5.1) mu g/L, lower than that of the control group. (15.2 + 8.1) mu g/L (t=-6.899, P0.001). The exposure level was stratified according to the median of MC-LR in the control group (0.042 mu g/L). The difference of GSH content in the low exposure and high exposure group of the liver cancer group was not statistically significant (t=-1.290, P=0.200), and the content of GSH in the low exposed population in the control group was higher than that of the high exposure group (t=2.090, P=0.038). Conclusion Guangxi The level of serum MC-LR in the patients with primary liver cancer was higher than that of the healthy people. The content of GSH in the healthy people with high exposure to.MC-LR was lower than that in the healthy population. The serum GSH content was lower than that of the MC-LR low exposure population.
【作者单位】：广西医科大学公共卫生学院环境卫生学教研室;广西高校高发疾病预防与控制研究重点实验室;广西医科大学附属肿瘤医院检验科;
【基金】：国家自然科学基金资助项目(81360420,81660529) 广西自然科学基金资助项目(2015GXNSFAA139120)
【分类号】：R735.7

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