沙利度胺防治鼻咽癌放射性口腔黏膜炎的疗效观察

发布时间：2018-06-25 18:29

本文选题：沙利度胺 + 放射性口腔黏膜炎　；参考：《中国肿瘤临床》2017年23期

【摘要】：目的:观察沙利度胺防治鼻咽癌(nasopharyngeal carcinoma,NPC)放射性口腔黏膜炎(radiation-induced oral mucositis,RIOM)的疗效。方法:2015年5月至2016年8月就诊于玉林市第一人民医院60例NPC患者随机分配进入试验组和观察组。试验组在放射治疗开始口服沙利度胺片,并用生理盐水+庆大霉素+地塞米松混合液漱口,对照组自放疗开始仅用生理盐水+庆大霉素+地塞米松混合液漱口。观察两组RIOM发生时间及程度。结果:试验组RIOM的发生率低于对照组,差异具有统计学意义(P0.05),试验组3、4级RIOM的发生率低于对照组,差异具有统计学意义(P0.05)。两组客观缓解率差异无统计学意义(P0.05);试验组和对照组口腔照射剂量体积在平均剂量、V30、V35、V40、V45、V50、V54方面差异均无统计学意义(P0.05);试验组和对照组在营养制剂、激素、抗生素使用方面差异均无统计学意义(P0.05);两组嗜睡、周围神经毒性、血液学毒性、胃肠道反应方面差异均无统计学意义(P0.05)。结论:沙利度胺可降低NPC的RIOM的发生率及严重程度。
[Abstract]:Objective: to observe the therapeutic effect of thalidomide on radiation-induced oral mucositis (RIOM) of nasopharyngeal carcinoma (NPC). Methods: from May 2015 to August 2016, 60 NPC patients in the first people's Hospital of Yulin City were randomly assigned to the experimental group and the observation group. The experimental group received oral salidomide tablets at the beginning of radiotherapy and gargled with gentamicin dexamethasone mixed with saline, while the control group only gargled with gentamicin dexamethasone mixture at the beginning of radiotherapy. The time and degree of RIOM in both groups were observed. Results: the incidence of RIOM in the experimental group was lower than that in the control group (P0.05), and the incidence of RIOM in the trial group was lower than that in the control group (P0.05). There was no significant difference in the objective remission rate between the two groups (P0.05); there was no significant difference in the mean dose volume of oral cavity irradiation between the test group and the control group (P0.05); There was no significant difference in antibiotic use (P0.05); there was no significant difference in somnolence, peripheral neurotoxicity, hematological toxicity and gastrointestinal reaction between the two groups (P0.05). Conclusion: thalidomide can reduce the incidence and severity of RIOM in NPC.
【作者单位】：玉林市第一人民医院肿瘤科;赣南医学院第一附属医院肿瘤科;
【分类号】：R739.63

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