反义RNA与肝癌的研究进展

发布时间：2018-06-27 04:44

本文选题：肝癌 + 反义RNA　；参考：《安徽医科大学学报》2017年04期

【摘要】：反义RNA是一类能与特异性mRNA互补并从翻译、转录或转录后水平上高度特异地抑制靶基因表达的RNA分子。肝癌是全球最常见且致命的恶性肿瘤。肝癌组织的无限增殖、侵袭转移、放化疗耐受等能力成为其无法治愈并不断恶化的重要原因。反义RNA在肝癌肿瘤中异常表达,肿瘤的恶性表型维持需要众多反义RNA的参与。近年来,利用反义RNA技术治疗恶性肿瘤已经成为了一个新的研究方向,本文对这一技术治疗肝癌进行了综述。
[Abstract]:Antisense RNA is a class of RNA molecules that complement the specific mRNA and highly specifically inhibit the target gene expression from the translation, transcription or post transcriptional level. Liver cancer is the most common and fatal malignant tumor in the world. The unlimited proliferation, invasion and metastasis, and chemotherapy tolerance of liver cancer are the important reasons for its inability to cure and continue to deteriorate. Antisense RNA is abnormally expressed in cancer of the liver, and the maintenance of malignant phenotype of the tumor requires the participation of many antisense RNA. In recent years, the use of antisense RNA technology to treat malignant tumors has become a new research direction. This paper reviews this technique for the treatment of liver cancer.
【作者单位】：扬州大学医学院生物化学教研室;扬州大学表观遗传学及表观基因组学研究所;
【基金】：国家自然科学基金(编号:81372237、81671056、91540117) 国家重点研发计划(编号:2016YFC1303604)
【分类号】：R735.7

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