非小细胞肺癌组织HMGB1表达临床意义Meta分析

发布时间：2018-06-27 06:22

本文选题：肺癌 + 癌　；参考：《中华肿瘤防治杂志》2017年09期

【摘要】：目的多项研究表明,高迁移族蛋白B1(hight mobility group box 1,HMGB1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)的发生发展中起到关键作用,本研究旨在通过Meta分析评价NSCLC组织HMGB1的表达与各临床病理参数相关性。方法计算机检索PubMed、相关期刊论文、万方数据库和维普数据库中NSCLC组织HMGB1表达情况与各临床病理参数相关性的文章,搜索时限为2000-01-2016-12,经过两名作者独立评价文献质量后,采用Revman 5.1软件对纳入的研究进行Meta分析。结果共检索到125篇文献,根据纳入标准总计6篇文献符合要求被纳入分析,累计病例536例。Meta分析示,HMGB1蛋白的表达水平与患者的性别无显著相关性(P0.05),而与患者临床分期、组织分化程度、病理类型及是否有淋巴结转移密切相关,均P0.05。临床分期较晚(P=0.003)、肿瘤分化程度较低(P0.05)、有淋巴结转移(P0.000 01)、病理类型为腺癌(P=0.001)的癌组织HMGB1阳性表达率较高。结论 NSCLC患者癌组织HMGB1的表达情况与患者临床分期、组织分化程度、病理类型及是否有淋巴结转移密切相关,有望成为判定NSCLC侵袭、转移、耐药及预后的重要标记物。但纳入的研究样本量小,质量一般,仍需要更多大样本、多中心和多因素分析的临床研究进一步证实。
[Abstract]:Objective to evaluate the correlation between the expression of HMGB1 and the clinicopathological parameters of non-small cell lung cancer (NSCLC) by meta-analysis, which indicates that HMGB1 plays a key role in the development of non-small cell lung cancer (NSCLC). Methods A computer-based search was conducted for articles on the correlation between the expression of HMGB1 and clinical pathological parameters in PubMed, Chinese Journal Full-text Database, Wanfang Database and Wiper Database. The search time was 2000-01-2016-12. After two authors independently evaluated the quality of the literature, the results were analyzed. Meta-analysis of the included study was carried out by using Revman 5.1 software. Results A total of 125 articles were retrieved. According to the inclusion criteria, a total of 6 articles were included in the analysis. 536 cases. Meta-analysis showed that there was no significant correlation between the expression level of HMGB1 protein and the gender of the patients (P0.05), but it was correlated with the clinical stage of the patients. The degree of tissue differentiation, pathological type and lymph node metastasis were closely related to each other (P 0.05). The positive expression rate of HMGB1 was higher in carcinoma with lymph node metastasis (P0. 00001) and adenocarcinoma (P0. 001) than that with late clinical stage (P0. 003), low tumor differentiation (P0.05) and lymph node metastasis (P0. 00001). Conclusion the expression of HMGB1 in NSCLC is closely related to the clinical stage, histological differentiation, pathological type and lymph node metastasis. HMGB1 may be an important marker for judging the invasion, metastasis, drug resistance and prognosis of NSCLC. However, the sample size and quality of the studies involved are small, and more large samples are needed, which are further confirmed by multicenter and multivariate analysis.
【作者单位】：武汉大学人民医院放疗科;山东大学附属山东省肿瘤医院放疗科;
【分类号】：R734.2

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