微流控芯片分选临床样品中循环肿瘤细胞的研究进展

发布时间：2018-06-28 04:41

  本文选题：临床样品 + 微流控芯片　； 参考：《色谱》2017年01期

【摘要】：癌症作为常见病正严重威胁着我国乃至全球居民的健康。循环肿瘤细胞(CTCs)是一类由癌变部位释放并进入血液中的癌细胞,其在癌症的早期诊断、个体化及肿瘤转移机制研究等方面的作用正逐渐被发现和认可,但由于血液中的CTCs含量极少,对其分选极具挑战。微流控芯片作为一种微型化、高通量、集成化平台,在CTCs研究中彰显了独特的优势,相关报道也越来越多。随着研究的深入,微流控芯片技术不再局限于基于模型样品的方法学开发,而是更注重于能否用于临床实际样品中CTCs的检测,但目前未见该角度的综述报道。为此,文章综述了近年来用于临床实际样品CTCs分析的微流控芯片分选技术,并探讨了微流控芯片用于CTCs分选的发展趋势。
[Abstract]:As a common disease, cancer is a serious threat to the health of Chinese and even global residents. Circulating tumor cells (CTCs) are a kind of cancer cells released from cancerous sites and entered the blood. Their roles in the early diagnosis of cancer, individualization and the study of tumor metastasis mechanism are gradually being discovered and recognized. However, because of the very small amount of CTCs in the blood, the separation of CTCs is very challenging. As a miniaturized, high-throughput and integrated platform, microfluidic chip has demonstrated its unique advantages in CTCs research and has been reported more and more. With the deepening of research, microfluidic chip technology is no longer limited to the development of model-based methodology, but more focused on whether it can be used in the detection of CTCs in clinical samples. In this paper, the microfluidic chip sorting technology used for CTCs analysis of clinical samples in recent years is reviewed, and the development trend of microfluidic chips for CTCs sorting is discussed.
【作者单位】： 天津大学药物科学与技术学院天津化学化工协同创新中心天津市现代药物传递及功能化高效能转化重点实验室;
【基金】：国家自然科学基金项目(21375093,21605112) 高等学校博士学科点专项科研基金项目(20130032120081) 天津市应用基础与前沿技术研究计划青年项目(15JCQNJC43200)~~
【分类号】：R730.4
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本文编号：2076778